◀ Back to NOS2

IRS1 — NOS2

Text-mined interactions from Literome

Sugita et al., J Biol Chem 2005 : Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells ... These findings indicate that iNOS reduces IRS-1 expression in skeletal muscle via proteasome mediated degradation and thereby may contribute to obesity related insulin resistance
Fujimoto et al., Diabetes 2005 (Diabetes Mellitus, Type 2...) : iNOS inhibitor also increased the protein expression of insulin receptor substrate (IRS)-1 and -2 1.5- and 2-fold, respectively, and enhanced IRS-1- and IRS-2 mediated insulin signaling in the liver of ob/ob mice
Xu et al., Mol Endocrinol 2007 (Insulin Resistance...) : Recombinant CRP suppressed insulin induced NO production, inhibited the phosphorylation of Akt and endothelial nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner