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CRH — NOS2
Text-mined interactions from Literome
Weidenfeld et al., Neuroendocrinology 1999
:
These results suggest that : ( 1 ) NO is involved in modulation of the HPA axis responses to neural stimuli which are not dependent on immune factors, ( 2 ) the effect of NO is mediated by inhibition of hypothalamic ME
CRH-41 secretion, and ( 3 ) this effect is probably
mediated by neuronal NOS and not by
inducible NOS
Cantarella et al., Br J Pharmacol 2001
:
Divergent
effects of
corticotropin releasing hormone on endothelial cell
nitric oxide synthase are associated with different expression of CRH type 1 and 2 receptors ... In fact, anti-Svg-30 inhibited
CRH induced increase of nitrite release and
iNOS expression in HUVEC cells
Karteris et al., J Clin Endocrinol Metab 2005
(Birth Weight...) :
In placental explants,
CRH and UCN
induced mRNA and protein expression of eNOS, but not
inducible NOS , and also caused an acute increase in cGMP levels ( maximal stimulation, 80-90 % above basal ; P < 0.05 )
Ralph et al., Am J Pathol 2007
(Arthritis...) :
CRH enhanced the expression of
nitric-oxide synthase ( NOS III ) to promote NO production from CRH-R1alpha expressing cells
Jain et al., Am J Obstet Gynecol 1997
:
The relaxation induced by corticotropin releasing factor in aortic rings from nonpregnant rats decreased after deendothelization and treatment with N omega-nitro-L-arginine methyl ester ( a
nitric oxide synthase inhibitor ), LY-83,583 ( a guanylate cyclase inhibitor ), or alpha-helical
corticotropin releasing factor 9-41 ( a corticotropin releasing factor antagonist )
Raber et al., Brain research. Brain research reviews 1998
(Disease Models, Animal...) :
The IFNalpha stimulated release of AVP and
CRH appears to be mediated by cyclic GMP production, and this release by IFNalpha and IL-2 may be
mediated in part by activation of constitutive
nitric oxide synthase