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EPHB2 — IL12A

Text-mined interactions from Literome

Feng et al., J Immunol 1999 : In contrast, while p38 promotes induction of IL-12 ( p40 ) mRNA, ERK activation suppresses LPS mediated IL-12 transcription
Gollob et al., J Immunol 2000 (Immunologic Deficiency Syndromes...) : An examination of cytokine signaling revealed that STAT4 and extracellular regulated kinase 1 (ERK1) activation by IL-12 was intact, whereas the activation of STAT1, -3, and -5 by IL-12 was lost
Yanagawa et al., J Leukoc Biol 2002 : These findings suggest that TNF-alpha induced ERK activation negatively controls maturation and IL-12 production in murine DC
Xia et al., Scand J Immunol 2003 : In addition, inhibition of ERK by PD98059 significantly suppressed IL-10 and increased the IL-12 production ... The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of ERK involves the differential production of IL-10 and IL-12 by activated DCs
Kikuchi et al., Immunol Lett 2003 : It seems that roles of ERK and p38 MAPK for IL-12 production are developmentally changed in murine DC
Chino et al., Int Immunopharmacol 2005 (MAP Kinase Signaling System) : Treatment with chemical inhibitors of NF-kappa B and p38 mitogen activated protein kinases ( MAPKs ) in vitro inhibited LPS induced IL-12 production, whereas JNK and ERK inhibitors increased IL-12 production
Correa et al., Br J Pharmacol 2005 : 3 The inhibitory effect of JWH-133 ( 100 nM ) on IL-12p40 production may involve extracellular regulated kinase ( ERK1/2 ) signaling : ( i ) JWH-133 induced a greater and sustained activation of ERK1/2 kinase in comparison with the level of activation observed following LPS ; ( ii ) the inhibition of ERK1/2 by the specific inhibitor PD98059 increased LPS induced IL-12p40 production in the presence or absence of JWH-133 suggesting a negative regulation of ERK pathway on IL-12p40 biosynthesis
Kondadasula et al., Blood 2008 : Retroviral transfection of ERK1 into primary human NK cells substantially increased IFN-gamma production in response to immobilized IgG and IL-12 , while transfection of human NK cells with a dominant negative ERK1 abrogated IFN-gamma production
Zhang et al., Hum Immunol 2008 : Also, IL-12 augmented the expression of cytotoxic effector molecules, TRAIL and perforin, and the phosphorylation of STAT1, STAT4, and ERK1/2 , which may also contribute to lysis by NK cells
Canda-Sánchez et al., Immunobiology 2009 : IL-12 dependent activation of ERK1/2 in human T lymphoblasts
Kang et al., Cytokine 2009 : Induction of IL-12 by LMM in peritoneal macrophages involved NF-kappaB, p38 and JNK, but not ERK1/2
Saraiva et al., Immunity 2009 : We showed that development of IL-10 producing Th1 cells required high T cell receptor ( TCR ) ligation, sustained ERK1 and ERK2 MAP kinases phosphorylation, and IL-12 induced STAT4 transcription factor activation
Ju et al., Eur J Immunol 2009 (Melanoma, Experimental) : Activation of p38 MAP kinase, but not ERK or JNK, by either TCR-stimuli or IL-12 and IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells, resulting in reduced production of IFN-gamma
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-12 p40, and the activation of ERK1/2 and p38
Boucher et al., Viral Immunol 2010 (HIV Infections...) : In THP-1 cells, p38, ERK , and JNK inhibition increased NF-kappaB and Sp1 binding to the IL-12p40 promoter, while inhibiting AP-1 binding
Xuan et al., Cell Physiol Biochem 2010 : Both LPS and GA stimulated the production of IL-6, IL-10, IL12p70 and TNFalpha in a p38- and/or ERK dependent manner
Rastogi et al., Am J Respir Crit Care Med 2011 (Sarcoidosis, Pulmonary) : Inhibition of p38, but not ERK , attenuated production of both IL12/IL23p40 and TNF-a
Zhang et al., Cell Mol Immunol 2012 : Interestingly, although p38 was required for HKBA phagocytosis and phagosome maturation, ERK1/2 did not affect these processes but negatively regulated IL-12 production ... Furthermore, Ras-guanine nucleotide releasing protein 1 ( RasGRP1 ) mediated the TLR2 induced ERK1/2 activation and inhibition of IL-12p40 production
Hedl et al., Gastroenterology 2012 : In mouse macrophages, which do not produce IL-1 in response to PRR stimulation alone, addition of exogenous IL-1 reversed the ERK mediated inhibition of IL-12p40