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CXCR4 — LCK
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4 complex (CXCL12-CXCR4)
→
LCK (LCK)
(modification, activates)
Inngjerdingen et al., Blood 2002*
Evidence: mutant phenotype, assay
Text-mined interactions from Literome
Su et al., J Immunol 1999
:
gp120, but not SDF-1alpha, induced rapid tyrosine phosphorylation of src-like kinase
p56lck in CD4+ T cells, whereas both gp120 and SDF-1alpha
caused phosphorylation of the
CXCR4
Van Drenth et al., J Immunol 2000
:
Desensitization of CXC
chemokine receptor 4 , mediated by IL-16/CD4, is
independent of
p56lck enzymatic activity