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ACE — PTGS2

Text-mined interactions from Literome

Cheng et al., J Clin Invest 1999 : To determine whether increased COX-2expression in response to ACE inhibition mediated increases in renin production, rats were treated with captopril for one week with or without the specific COX-2 inhibitor, SC58236
Cheng et al., American journal of physiology. Renal physiology 2000 : We have previously shown that cyclooxygenase-2 (COX-2) is localized to the cortical thick ascending limb of the loop of Henle ( cTALH ) /macula densa of the rat kidney, and expression increases in response to low-salt diet and/or angiotensin converting enzyme (ACE) inhibition
Hay et al., J Emerg Med 2002 (Hyperkalemia...) : Fatal hyperkalemia related to combined therapy with a COX-2 inhibitor, ACE inhibitor and potassium rich diet
Kohlstedt et al., Hypertension 2005 : The ramiprilat induced , ACE dependent increase in COX-2 expression and promoter activity ( both 1.5- to 2-fold greater than control ) was prevented by the inhibition of JNK ... These results indicate that ACE signaling may underlie the increase in COX-2 and prostacyclin levels in patients treated with ACE inhibitors
Ohgami et al., Invest Ophthalmol Vis Sci 2005 (Disease Models, Animal...) : ACE also suppressed LPS induced iNOS and COX-2 protein expressions in RAW 264.7 cells in vitro in a dose dependent manner
Zhang et al., Proc Natl Acad Sci U S A 2006 : Cortical COX-2 induction by angiotensin converting enzyme (ACE) inhibitors or AT(1) receptor blockers ( ARBs ) suggests that angiotensin II may inhibit cortical COX-2 by stimulating the AT(1) receptor pathway ... Cortical COX-2 increased to similar levels in response to ACE inhibition in both knockout and WT mice