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CASP8 — CASP9
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhuang et al., Exp Cell Res 1999
:
Caspase-8 mediates
caspase-3 activation and cytochrome c release during singlet oxygen induced apoptosis of HL-60 cells
Raoul et al., J Cell Biol 1999
:
Motoneurons resistant to Fas activation expressed high levels of
FLICE-inhibitory protein (FLIP) , an endogenous
inhibitor of
caspase-8 activation
Okamoto et al., Rheumatology (Oxford) 2000
(Arthritis, Rheumatoid) :
Caspase-8-specific inhibitor
suppressed the activation of
caspase-3 after Fas ligation on RA synoviocytes
Robertson et al., Crit Rev Toxicol 2000
:
Caspase-9 can signal downstream and
activate pro-caspase-3 and -7
Hernandez et al., Surgery 2001
(Colonic Neoplasms) :
Western blots were performed to assess intracellular expression of
Flice-like inhibitory protein (FLIP) , a
caspase inhibitor
Viswanath et al., J Neurosci 2001
(Disease Models, Animal...) :
Caspase-9 activation
results in downstream
caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson 's disease ...
Caspase-9 inhibition
prevented the activation of both caspase-3 and
caspase-8 and also inhibited Bid cleavage, but not cytochrome c release
Thomas et al., Surgery 2002
(Pancreatic Neoplasms) :
FLICE-like inhibitory protein (FLIP) , an
inhibitor of
caspase-8 , ( also known as FLICE ) is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB) and can contribute to TRAIL resistance
Robertson et al., Toxicology 2002
(Necrosis) :
Caspase-9 can signal downstream and
activate pro-caspase-3 and -7
Xu et al., Anticancer Res 2003
(Pancreatic Neoplasms) :
Caspase-8 and -3 activities were increased by TRAIL treatment and apoptosis was largely
blocked by
caspase-8 and -3 inhibitors
Fujii et al., Infect Immun 2003
:
Caspase-8 is known to activate Bid, and a specific inhibitor of
caspase-8 prevented the mitochondrial damage
Cuello et al., Cell Death Differ 2004
:
Caspase-9 may further
activate caspase-8 , generating an amplification loop
Perchellet et al., Anticancer Drugs 2004
:
Caspase-2 and -8 may both act upstream of mitochondria to promote Cyt c release, but
caspase-2 is already maximally
activated 6 h after 4 microM DAU or TT13 treatments, whereas DAU- or TT-induced caspase-8 and -9 activities peak at 9 h. Pre-treatments with 15 microM of the caspase-2 inhibitor benzyloxycarbonyl ( z ) -Val-Asp-Val-Ala-Asp ( VDVAD ) -fluoromethyl ketone ( fmk ) totally block DAU- and TT13 induced caspase-2, -8 and -9 activities, whereas pre-treatments with 15 microM of the caspase-8 inhibitor z-Ile-Glu-Thr-Asp ( IETD ) -fmk prevent DAU and TT13 from inducing caspase-8 activities without affecting their caspase-2- and -9-inducing activities, suggesting that the induction of apical caspase-2 activity by these drugs may be a critical upstream event required for the activation of other downstream caspases, including caspase-9 and the mitochondrial amplification loop through caspase-8
Martin et al., J Biol Chem 2005
:
Caspase-9 cleaves and
activates effector caspases, predominantly
caspase-3 , resulting in the demise of the cell
Maitra et al., Crit Care Med 2005
(Sepsis) :
Caspase-8 activates
caspase-3 , which in turn degrades fibronectin and focal adhesion kinase and leads to disruption of hepatic architecture and integrity
Lang-Rollin et al., Apoptosis 2005
:
Caspase 9 and 3 are processed, cytochrome c is released from the mitochondria and a dominant negative form of
caspase 9
prevents death
Daher et al., Exp Dermatol 2006
:
Caspase-9-DN and zLEHD-fmk both
suppressed caspase-9 , -3, and -8 activity after UVB exposure, as well as proteolytic processing of procaspase-3 into its active form, DNA fragmentation factor 45 cleavage, and internucleosomal DNA fragmentation
Miyao et al., Otol Neurotol 2006
(Cholesteatoma, Middle Ear) :
Caspase-8 , which is activated by the induction of tumor necrosis factor-alpha,
leads to activation of
caspase-3 , which activates apoptotic nucleases
Wu et al., Cell Mol Life Sci 2006
:
Caspase-8 played important roles in the activation of
caspase-3 and induction of apoptosis, whereas the role of the caspase-9 was limited
Yamaguchi et al., Biochim Biophys Acta 2006
(Carcinoma, Hepatocellular...) :
We demonstrated that
Adv-Casp8 increased expression of active forms of
caspase-8 in MOI dependent manner
Faragher et al., Mol Biol Cell 2007
(Breast Neoplasms) :
Caspase-8 activates cytoplasmic
caspase-7 , which is likely to be the primary caspase responsible for cleavage of CENP-C and INCENP, a key chromosomal passenger protein
Uchiyama et al., Infect Immun 2007
(Necrosis) :
Caspase-9 activation was also detected in H37Rv infected cells, but H37Ra never
induced such
caspase-9 activation
Nica et al., Cell cycle (Georgetown, Tex.) 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
C6-ceramide induces cleavage of Caspase-8 and
Caspase-9 , but only
Caspase-8 is
required for apoptosis
Zhao et al., Tohoku J Exp Med 2008
(Myocardial Infarction...) :
Caspase-9 cleaves and
activates caspase-3
Tang et al., Oncol Rep 2009
(Adenocarcinoma...) :
Caspase-9 and -3 inhibitors almost completely
suppressed HCT induced
caspase-9 and -3 activities
Shi et al., Toxicol Lett 2010
:
Caspase 9 inhibition
blocked the TNP induced activation of
caspase 3 significantly
Ohsawa et al., Proc Natl Acad Sci U S A 2010
:
Maturation of the olfactory sensory neurons by
Apaf-1/caspase-9 mediated
caspase activity ... Here, we provide unique evidence that
Apaf-1/caspase-9 mediated
caspase signaling regulates the development of olfactory sensory neurons ( OSNs ), which includes axonal projection, synapse formation, and maturation of these neurons
Pesakhov et al., Nutr Cancer 2010
(Leukemia, Myeloid, Acute) :
Caspase-8 inhibition abrogated Bid cleavage and strongly
reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8 dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid
Moujalled et al., Cell Death Differ 2012
:
In mouse embryonic fibroblasts, neither caspase-8 nor cellular
FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-?B, but
caspase-8 is
required for TNF to cause cell death, and induction of FLIP by NF-?B is required to prevent it
Wang et al., PloS one 2012
:
Caspase assay demonstrated that Caspase-3, -8, -9 enzyme activities in newt testis were significantly elevated after heat shock ( 40°C 2 h ), cold exposure ( 4°C 12 h ), and cadmium exposure ( Cd 36 h ), while Caspase3 and
Caspase8 activities were
increased with
Caspase9 significantly decreased after starvation treatment
Liu et al., PloS one 2012
:
Caspase-9 inhibitor could
inhibit activation of
pro-caspase-3 , and the inhibition of the function of Apaf-1 with FSBA blocked apoptosis, hinting that Apaf-1 could be involved in Sl-1 cell apoptosis induced by AfMNPV
Sata et al., J Biol Chem 1998
:
Here, we show that endothelial cell apoptosis by OxLDL and LPC-C16 : 0 was dose dependent and correlated with down-regulation of
FLICE-inhibitory protein (FLIP) , an intracellular
caspase inhibitor
Yamashita et al., Blood 1999
:
Caspase-8 activated
caspase-3 and T18 in neutrophil cytoplasmic extracts