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ALOX5 — RELA

Text-mined interactions from Literome

Bonizzi et al., Mol Cell Biol 1999 (Adenocarcinoma) : Reactive oxygen intermediate dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity
Anthonsen et al., J Biol Chem 2001 : We show that in addition to inhibitors of secretory and cytosolic PLA(2)s, 5-lipoxygenase inhibitors attenuate TNF-alpha- and IL-1beta stimulated NF-kappaB activation
Ye et al., J Pharmacol Exp Ther 2004 (Colonic Neoplasms) : However, 5-lipoxygenase inhibition had no effect on alpha7-nAChR mRNA expression, but significantly inhibited cell proliferation and activation of NF-kappaB and cyclooxygenase-2, whereas NF-kappaB-specific inhibitor caffeic acid phenethyl ester reduced both cell proliferation and cyclooxygenase expression induced by NNK without affecting alpha7-nAChR mRNA level and 5-lipoxygenase expression
Chung et al., Toxicological sciences : an official journal of the Society of Toxicology 2008 (Inflammation) : In addition, the inhibition of 5-LO by AA861 markedly reduced AcQ induced nuclear factor kappa B (NF-kappa B) activation
Roumestan et al., Clin Exp Allergy 2008 : We then investigated whether these drugs affect NF-kappaB and AP-1 activities in A549 lung epithelial cells, and whether this potential regulation involves H1-receptor and 5-LO
Lee et al., J Immunol 1997 : In transiently transfected HUVECs, NF-kappa B-dependent gene expression was inhibited by 5-lipoxygenase inhibitors
Griswold et al., Inflamm Res 1998 (Dermatitis, Contact...) : The thickness and influx of neutrophils into the treated ears was measured as was the effects of the azaspiranes on 5-lipoxygenase activity, cyclooxygenase activity, prostaglandin and leukotriene synthesis, and the activation of the transcription factor NF-kappaB