Gene interactions and pathways from curated databases and text-mining

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CEBPB — JUN

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Employing gel shift assays, NF-kappaB, C/EBPbeta , and c-Jun were constitutively activated in RA FLS, but only NF-kappaB and c-Jun activity increased after IL-1beta
Lin et al., DNA Cell Biol 2002 (Acute-Phase Reaction) : Transcriptional activation of C/EBPbeta gene by c-Jun and ATF2 ... Cotransfection experiments showed that ATF2 and c-Jun activate the C/EBPbeta gene expression cooperatively through URE2 and URE4, and this activation was greatly increased under the treatment of low concentration of anisomycin
Cho et al., Mol Pharmacol 2003 : AP-1 decoy oligonucleotide suppressed C2-potentiated C/EBP beta expression, indicating that AP-1 was responsible for C2-mediated C/EBP beta expression ... These results demonstrate that C2 increases C/EBP beta mediated COX-2 induction by LPS and that the pathway of JNK1 but not ERK1/2 is responsible for C/EBP beta activation involving activator protein-1 mediated enhanced C/EBP beta expression
Gagliardi et al., J Biol Chem 2003 : In contrast, the over-expression of C/EBPbeta caused a dramatic reduction in the levels of AP-1 proteins
Grondin et al., Mol Cell Biol 2007 : Our observations indicate that the IL-1beta locus is occupied by PU.1 and C/EBPbeta and poised for expression and that c-Jun enhances transcription by facilitating a rate limiting step, the assembly of the RNA polymerase II preinitiation complex, with minimal effect on the local chromatin status
Healy et al., Am J Physiol Cell Physiol 2008 : Individual gene knockdown experiments demonstrate the direct regulation of C/EBPbeta expression by c-Jun , and the critical roles of both c-Jun and C/EBPbeta in shear induced COX-2 synthesis