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CEBPB — JUN
Pathways - manually collected, often from reviews:
-
FastForward regulation:
JUN
→
CEBPB
(transcriptional regulation, increase)
Healy et al., Am J Physiol Cell Physiol 2008*
Evidence: REG
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
→
NKG2E (KLRC3)
(transcription, activates)
Levy et al., Endocrinology 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
CEBPB (CEBPB)
→
AP1 complex (FOS-JUN)
(transcription, activates)
Schumann et al., Mol Cell Biol 1996*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
HSF2 (HSF2)
→
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
→
CEBPB (CEBPB)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
CEBPB (CEBPB)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
Text-mined interactions from Literome
Georganas et al., J Immunol 2000
(Arthritis, Rheumatoid) :
Employing gel shift assays, NF-kappaB,
C/EBPbeta , and c-Jun were constitutively activated in RA FLS, but only NF-kappaB and
c-Jun activity
increased after IL-1beta
Lin et al., DNA Cell Biol 2002
(Acute-Phase Reaction) :
Transcriptional
activation of
C/EBPbeta gene by
c-Jun and ATF2 ... Cotransfection experiments showed that ATF2 and
c-Jun activate the
C/EBPbeta gene expression cooperatively through URE2 and URE4, and this activation was greatly increased under the treatment of low concentration of anisomycin
Cho et al., Mol Pharmacol 2003
:
AP-1 decoy oligonucleotide suppressed C2-potentiated C/EBP beta expression, indicating that
AP-1 was
responsible for C2-mediated
C/EBP beta expression ... These results demonstrate that C2 increases C/EBP beta mediated COX-2 induction by LPS and that the pathway of JNK1 but not ERK1/2 is responsible for C/EBP beta activation involving
activator protein-1 mediated enhanced
C/EBP beta expression
Gagliardi et al., J Biol Chem 2003
:
In contrast, the over-expression of
C/EBPbeta caused a dramatic reduction in the levels of
AP-1 proteins
Grondin et al., Mol Cell Biol 2007
:
Our observations indicate that the IL-1beta locus is occupied by PU.1 and
C/EBPbeta and poised for expression and that
c-Jun enhances transcription by facilitating a rate limiting step, the assembly of the RNA polymerase II preinitiation complex, with minimal effect on the local chromatin status
Healy et al., Am J Physiol Cell Physiol 2008
:
Individual gene knockdown experiments demonstrate the direct
regulation of
C/EBPbeta expression by
c-Jun , and the critical roles of both c-Jun and C/EBPbeta in shear induced COX-2 synthesis