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RUNX1 — SMAD3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
CREB1 (CREB1)
→
SMAD3/SMAD4/RUNX1-3/PEBPB2 complex (SMAD3-SMAD4-RUNX3_RUNX1-CBFB)
(transcription, activates)
Hanai et al., J Biol Chem 1999, Pardali et al., J Biol Chem 2000, Zhang et al., J Biol Chem 2000
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
RUNX1-3/PEBPB2 complex (RUNX3_RUNX1-CBFB)
→
SMAD3/SMAD4 complex (SMAD3-SMAD4)
(modification, collaborate)
Hanai et al., J Biol Chem 1999, Pardali et al., J Biol Chem 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
RUNX1-3/PEBPB2 complex (RUNX3_RUNX1-CBFB)
→
SMAD3/SMAD4/RUNX1-3/PEBPB2 complex (SMAD3-SMAD4-RUNX3_RUNX1-CBFB)
(modification, collaborate)
Hanai et al., J Biol Chem 1999, Pardali et al., J Biol Chem 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
SMAD3/SMAD4/RUNX1-3/PEBPB2 complex (SMAD3-SMAD4-RUNX3_RUNX1-CBFB)
(modification, collaborate)
Hanai et al., J Biol Chem 1999, Pardali et al., J Biol Chem 2000
Evidence: mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Phimphilai et al., J Bone Miner Res 2006
:
However,
RUNX2 did not
increase the ability of this BMP to activate
SMAD , ERK, p38, and JNK pathways
Laronda et al., Dev Biol 2013
(Vaginal Diseases) :
This
SMAD dependent dNp63 activation
required RUNX1 , a binding partner of SMADs
Kurokawa et al., Blood 1998
(Leukemia, Myeloid...) :
AML1/Evi-1 interacts with Smad3, an intracellular mediator of TGF-beta signaling, through the first zinc finger domain, and
represses the
Smad3 activity, as Evi-1 does