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CCR7 — CXCR4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sato et al., J Immunol 2000
:
Stimulation of mature DCs with TGF-beta 1 also
enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and
CXCR-4 , and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of
CCR-7 and chemotactic migratory ability to MIP-3 beta
Murakami et al., J Dermatol Sci 2004
(Lung Neoplasms...) :
In particular, we describe
roles for CC
chemokine receptor 7 (CCR7) in lymph node metastasis,
CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma
Humrich et al., Immunology 2006
:
In conclusion, our data support the fundamental
role of
CCR7 for rapidly guiding DC toward secondary lymphoid organs at an extra- and intracellular molecular level and on the contrary render
CXCR4 a weaker contributor to directional migration of DC during inflammation