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GLI2 — SHH
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Du et al., Differentiation 2001
:
Together, these data suggest that further Hhs, other than Shh, are also involved in the induction and differentiation of slow muscle cells and that
Gli2 is
required by
Shh , Twhh, and Ehh, thus playing a key role in the induction and differentiation of slow muscle cells
Mill et al., Genes Dev 2003
:
Furthermore, only a constitutively active form of Gli2, but not wild-type
Gli2 , can
activate Shh-responsive gene expression and promote cell proliferation in Shh ( -/- ) skin ... Together, our results suggest that
Shh dependent
Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators
Qi et al., Mol Cell Neurosci 2003
:
Gli2 is
required for normal
Shh signaling and oligodendrocyte development in the spinal cord
Blaess et al., Development 2006
:
Thus, the precise spatial and temporal
regulation of
Gli2A and Gli3R by
Shh is instrumental in coordinating mid/hindbrain development in three dimensions
Pan et al., Mol Cell Biol 2006
:
Our findings provide the first demonstration of a molecular mechanism by which the
Gli2 transcriptional activity is
regulated by
Shh signaling
Zhao et al., Mol Cell Biol 2006
:
Finally,
Sonic hedgehog (Shh) stimulates BMP-2 promoter activity and osteoblast differentiation, and the effects of Shh are
mediated by
Gli2
Barakat et al., EMBO Rep 2013
:
Conditional deletion of ILK or Smo also inhibits
SHh-driven activation of
Gli2 in the embryonic mouse cerebellum
Ruiz i Altaba et al., Development 1998
:
Because both Gli1 and
Gli2 are
induced by
Shh , these results establish a regulatory feedback loop triggered by Shh that restricts floor plate cells to the midline