Gene interactions and pathways from curated databases and text-mining

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CPOX — IL18

Text-mined interactions from Literome

Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Oku et al., Hum Reprod 2004 (Endometriosis) : The effects of IL-18 on cyclooxygenase (COX)-II gene expression were analysed in peritoneal fluid monocytes and endometriotic cells of endometriosis patients
Helmersson et al., Free radical research 2005 (Cardiovascular Diseases...) : This study investigated the longitudinal association between serum selenium ( s-Se ) and a golden standard indicator of oxidative stress in vivo ( 8-iso-prostaglandin F2alpha, a major F2-isoprostane ), an indicator of cyclooxygenase (COX) mediated inflammation ( prostaglandin F2alpha ), high sensitive C-reactive protein ( hsCRP ), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years
John et al., Histol Histopathol 2007 (MAP Kinase Signaling System) : The effects of IL-18 on the cartilage-specific matrix protein collagen type II, the cytoskeletal protein vinculin, the cell matrix signal transduction receptor beta-integrin, key signalling proteins of the MAPKinase pathway ( such as SHC ( Sarc Homology Collagen ) and activated MAPKinase [ERK-1/-2 ] ), the pro-inflammatory enzyme cyclo-oxygenase-2 (COX-2) and the apoptosis marker activated caspase-3 were evaluated by Western blot analysis and immunofluorescence labelling
Dean et al., J Biol Chem 1999 : We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts