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RNF19A — TNF

Text-mined interactions from Literome

Ajizian et al., J Infect Dis 1999 : Specific inhibitors of p38 and extracellular signal regulated kinase mitogen activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma
Salituro et al., Curr Med Chem 1999 (Cardiovascular Diseases) : Subsequent downstream events triggered by p38 activation result in the production of IL-1 and TNF-a , suggesting that inhibition of this enzyme may provide a useful therapeutic target for intervention in various diseases mediated by these cytokines
Brinkman et al., J Biol Chem 1999 : The study presented here shows that autoregulation of TNF-alpha gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) requires p38 mitogen activated protein ( MAP ) kinase activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element
Monier et al., J Infect Dis 2002 : Differential effects of p38- and extracellular signal regulated kinase mitogen activated protein kinase inhibitors on inducible nitric oxide synthase and tumor necrosis factor production in murine macrophages stimulated with Streptococcus pneumoniae
Azzolina et al., Cytokine 2002 (MAP Kinase Signaling System) : Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells
Murr et al., J Gastrointest Surg 2003 (Acute Disease...) : It was concluded that pretranscriptional regulation of TNF gene expression in Kupffer cells follows an orderly activation of p38-MAPK , ERK1/2, and SAPK/JNK that may not converge on NF-kappaB
Clermont et al., Cell Signal 2003 : ( 5 ) The p38 is activated by TNF and its inhibition by SB203580 sensitized the cells to TNF
Carter et al., J Surg Res 2003 (Disease Models, Animal...) : SB203580 inhibition of p38 activity did not affect HSP72 expression, or reverse NaArs inhibition of LPS induced TNF production
Nwariaku et al., J Appl Physiol 2003 : TNF increased pulmonary endothelial permeability in vitro and caused a rapid, sustained increase in endothelial p38 and extracellular signal regulated kinase MAPK activity
Brancho et al., Genes Dev 2003 (MAP Kinase Signaling System) : We show that MKK3 and MKK6are essential for tumor necrosis factor stimulated p38 MAPK activation
Séguin et al., J Cell Physiol 2003 (Arthritis...) : In both prechondrocytes and articular chondrocytes, TNFalpha induced concentration dependent activation of MEK1/2 and NF-kappaB, but not p38 or JNK
Lee et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Taken together, these studies suggest a mechanism whereby RIP1 may mediate the p38 MAP kinase response to TNF-alpha , by recruiting the MAP3K MEKK3
Bundy et al., Antioxid Redox Signal 2005 (Inflammation...) : N-Acetyl-L-cysteine ( 20 mM ) inhibited both H2O2- and TNFalpha induced p38 phosphorylation ( 14 +/- 7 and 37 +/- 4 % of control, respectively ) ... The mitochondrial complex I and III inhibitors, rotenone and antimycin A, and allopurinol partially inhibited H2O2- but not TNFalpha induced p38 activation
Yamawaki et al., J Clin Invest 2005 (Inflammation) : Normal flow inhibited TNF activation of JNK/p38 and VCAM1 expression
Jung et al., J Clin Immunol 2005 (MAP Kinase Signaling System...) : The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and ERK activation are essential for PPD induced TNF-alpha production, whereas p38, but not ERK, activation is essential for IL-10 secretion
Görtz et al., Arthritis Res Ther 2005 (Arthritis...) : In vivo, overexpression of TNF induced activation of p38MAPKalpha and ERK in the synovial membrane, whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis
Zhao et al., Cell Immunol 2005 (MAP Kinase Signaling System) : Although gAd partially increased cAMP concentration and PKA activity, it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus inhibiting TNF-alpha production
Chen et al., Zhonghua Shao Shang Za Zhi 2005 (Burns) : [ The modulating role of p38 mitogen activated protein kinase in the expression of tumor necrosis factor-alpha in hepatic cells and its role in hepatic injury in severely burned rats ]
Kimura et al., Life Sci 2006 (Myocardial Ischemia) : Ischemic preconditioning or p38 MAP kinase inhibition attenuates myocardial TNF alpha production and mitochondria damage in brief myocardial ischemia
Bellahcene et al., J Am Coll Cardiol 2006 : Tumor necrosis factor activates p38-MAPK , a stress-responsive kinase implicated in contractile depression and cardiac injury ... Tumor necrosis factor activates p38-MAPK in the intact heart and in isolated cardiac myocytes through MKK3
Choi et al., World J Gastroenterol 2006 : Interestingly, DA-9601 also selectively inhibited p38 kinase phosphorylation induced by TNF-alpha
Boyle et al., PLoS Med 2006 (Arthritis, Experimental...) : Activation of p38 required tumor necrosis factor alpha (TNFalpha) in the nervous system because IT etanercept ( a TNF inhibitor ) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis
Olson et al., Infect Immun 2007 : p38 mitogen activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens
Lewthwaite et al., Int Immunopharmacol 2007 (Inflammation) : Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of MEK1/2, the direct upstream activator of ERK1/2 ( PD98059 ), reduced the synthesis of IL-1beta, TNFalpha , IL-6 and IL-8 induced by either the chaperonins or LPS
Harhaji et al., Eur J Pharmacol 2007 (Necrosis) : On the other hand, aloe emodin did not affect TNF induced activation of p38 mitogen activated protein kinase or generation of reactive oxygen species
Xu et al., Anesth Analg 2007 (Chronic Disease...) : Conversely phosphorylated p38 ( p-p38 ) could induce the upregulation of TNF-alpha
Netea et al., Proc Natl Acad Sci U S A 2008 : Whereas the induction of TNFalpha , IL-1beta, and IL-6 by IL-32 is mediated by p38-MAPK , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3 dependent mechanisms
Chakir et al., Circulation 2008 (Bundle-Branch Block...) : In DHF, mitogen activated kinase p38 and calcium-calmodulin dependent kinase were disproportionally expressed/activated ( 50 % to 150 % ), and tumor necrosis factor-alpha increased in the late contracting ( higher-stress ) lateral versus septal wall
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : TNF stimulation induced p38 MAPK dependent phosphorylation of MK2 and HSP27
Liu et al., J Agric Food Chem 2008 : Moreover, we found that extracellular signal regulated kinase 1/2, Jun N-terminal kinase 1/2, and p38 mitogen activated protein kinase play important roles in the regulation of TNFalpha secretion in ZPF1 stimulated macrophages
Iftakhar-E-Khuda et al., Clin Exp Immunol 2009 (Niemann-Pick Diseases) : A p38 inhibitor reduced U18666A induced TNF-alpha production
King et al., J Biol Chem 2009 : Repression of TNFalpha induced p38 MAPK phosphorylation, NF-kappaB dependent transcription, and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors
Usui et al., J Pharmacol Sci 2010 (Atherosclerosis) : NAC inhibited TNF induced phosphorylation of JNK and p38 but not NF-kappaB
Shibata et al., Vet Immunol Immunopathol 2011 : In a cell line of canine epidermal keratinocyte, CPEK, stimulation with TNF-a induced not only the activation of nuclear factor-kappa B ( NF-?B ) but also the phosphorylation of c-Jun-N-terminal kinase (JNK) and mitogen activated protein kinase p38 ( p38 )
Rastogi et al., Am J Respir Crit Care Med 2011 (Sarcoidosis, Pulmonary) : Inhibition of p38 , but not ERK, attenuated production of both IL12/IL23p40 and TNF-a
Schlickeiser et al., J Immunol 2011 : Moreover, hybrid-type, but not complex-type, N-glycans are required for TNF-a induced p38-MAPK activation and subsequent phenotypic maturation of BMDCs ( MHC-II, CD86, CCR7 upregulation )
Hernandez et al., Eur J Pharmacol 2011 (Leprosy) : The drug also reduced M. leprae induced TNF-a production and inhibited p38 and ERK1/2 activation
Kim et al., Vascul Pharmacol 2012 (Atherosclerosis...) : Sulforaphane also suppressed TNF-a induced production of intracellular reactive oxygen species ( ROS ) and activation of p38 , ERK and JNK
Zhang et al., Cardiovasc Res 2012 (Endotoxemia...) : MKP1 attenuates ERK1/2 and p38 activation, inhibits myocardial TNF-a expression, and improves cardiac function in endotoxemia
Liu et al., Atherosclerosis 2012 : Furthermore, leonurine also suppressed the TNF-a activated p38 phosphorylation and I?Ba degradation
Chang et al., J Allergy Clin Immunol 2012 (Asthma) : TNF-a induced phosphorylated p38 mitogen activated protein kinase levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects, whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups
Koo et al., Mol Med Report 2013 (Aortitis) : Furthermore, AQEE suppressed the TNF-a induced phosphorylation of p38 mitogen activated protein kinase ( MAPK ) and reduced nuclear factor ?B ( NF-?B ; p65 ) nuclear translocation
Hochdörfer et al., Cell Signal 2013 : LPS induced production of TNF-a and IL-6 in mast cells is dependent on p38 but independent of TTP
Tu et al., J Ethnopharmacol 2013 (Kidney Diseases) : HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats, by way of reducing the infiltration and the activation of macrophages in glomeruli, and TNF-a protein expression in the kidney, as well as inhibiting p38MAPK signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo
Cheng et al., J Immunol 2013 (MAP Kinase Signaling System) : GILZ overexpression also inhibited TNF induced activation of p38 , ERK, and JNK MAPKs, as well as increased expression of the MAPK inhibitory phosphatase, MKP-1
Park et al., BMB Rep 2013 (Atherosclerosis) : Furthermore, P. vulgaris extract suppressed TNF-a induced phosphorylation of p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinase ( ERK )
Geng et al., J Clin Invest 1996 : In contrast, JNK and p38 are only activated by IL-1 or TNF , suggesting that these kinases participate in the induction of the catabolic program in cartilage
Winston et al., J Immunol 1997 : Activation of p38mapk , MKK3, and MKK4 by TNF-alpha in mouse bone marrow derived macrophages ... In this study, we have investigated the mechanism of activation of the p38mapk by TNF-alpha in mouse bone marrow derived macrophages
Schwenger et al., Mol Cell Biol 1998 : These findings provide evidence for a role of NaSal induced p38 MAPK activation in the inhibition of TNF signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates
Palmer et al., Mol Microbiol 1998 : The ability of the yopJ mutant to downregulate p38 and JNK and to inhibit production of TNF-alpha was restored by the expression of yopJ+ in trans
Matsumoto et al., J Allergy Clin Immunol 1998 : The specific p38 MAP kinase inhibitor, SB 203580, completely inhibited TNF-alpha- , IL-1alpha-, or PAF induced IL-8 protein and mRNA expression in BECs
Igarashi et al., J Clin Invest 1999 (Diabetes Mellitus, Experimental...) : However, p38 kinase activation by mannitol or tumor necrosis factor-alpha was not inhibited by GF109203X
Goebeler et al., Blood 1999 : We show that tumor necrosis factor-alpha (TNF-alpha) , a potent inflammatory activator of endothelium, leads to activation of MAP kinases ERK, p38 , and JNK in human umbilical vein endothelial cells ( HUVEC )