Brenne et al., Blood 2002
(Multiple Myeloma) :
Tumor necrosis factor (TNF) , another stimulator of myeloma cell growth, up-regulated the expression level of IL-21 receptor (IL-21R) , and combinations of TNF and IL-21 gave synergistic effects on myeloma cell proliferation
Andersson et al., Scand J Immunol 2008
(Arthritis, Rheumatoid...) :
IL-21R-Fc at the highest dose ( 100 microg/ml ) significantly reduced TNFalpha production by 50 %, IL-6 by 57 % and IL-1beta by 81 %