Gudi et al., J Environ Pathol Toxicol Oncol 2009
:
Additionally, Siva-1 also suppressed the activity of another crucial transcription factor AP-1 , and a common mediator of both these pathways is the adaptor protein TRAF2
Resch et al., J Cell Sci 2009
:
By contrast, Siva1 increased XIAP- and TNFalpha mediated AP1 activity and prolonged TNFalpha induced JNK activation, whereas knock down of Siva1 resulted in reduced JNK activation