◀ Back to SMAD3
CDKN1A — SMAD3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Pardali et al., J Biol Chem 2000
:
Role of
Smad proteins and transcription factor Sp1 in
p21 ( Waf1/Cip1 ) regulation by transforming growth factor-beta ... In this study we show that
Smad3 and Smad4 when overexpressed in HaCaT keratinocytes
lead to activation of the
p21 promoter ... Induction of the endogenous HaCaT p21 gene by TGF-beta1 is further enhanced after overexpression of Smad3 and Smad4, whereas dominant negative mutants of
Smad3 and Smad4 and the inhibitory Smad7 all
inhibit p21 induction by TGF-beta1 in a dose dependent manner
Medrano et al., Oncogene 2003
(Melanoma...) :
SKI also facilitates cell-cycle progression by targeting the RB pathway by at least two ways : it directly associates with RB and represses its activity when expressed at high levels, and indirectly, it represses
Smad mediated induction of
p21 ( Waf-1 ) This results in increased CDK2 activity, RB phosphorylation, and inactivation
Pardali et al., J Cell Physiol 2005
:
Based on the previously known ability of c-Myc to block p21 expression and epithelial growth arrest in response to TGF-beta1, we demonstrate that ectopic c-Myc expression can abrogate
Smad mediated
p21 induction by all TGF-beta and BMP receptors
Zhang et al., J Neurosurg 2006
(Glioma) :
Overall, the expression of the Smad2 and
Smad3 proteins was low in the glioma cell lines, the phosphorylation and nuclear translocation of Smad2 and Smad3 were impaired, and the TGFbeta receptor signal did not
affect the expression of the SnoN,
p21 , p15, cyclin D1, and CDK4 proteins
Sonegawa et al., J Mol Med (Berl) 2007
(Carcinoma, Squamous Cell) :
In A431 cells, S100C/A11,
Smad3 , and Smad4 were simultaneously transferred to the nuclei, and
p21 ( WAF1 ) was
induced upon exposure to TGFbeta
Chuang et al., J Cell Biochem 2007
:
Sp1 and
Smad3 are
required for high glucose induced
p21 ( WAF1 ) gene transcription in LLC-PK1 cells ... High glucose induced hypertrophy was
attenuated by
p21 ( WAF1 ) short interfering RNA and
Smad3 dominant negative plasmid transfection ... We concluded that high glucose induced hypertrophy via
Sp1-Smad2/3 dependent activation of
p21 ( WAF1 ) gene transcription in LLC-PK ( 1 ) cells
Kim et al., Arch Pharm Res 2007
:
Although it has been demonstrated that
p21WAF1/Cip1 could be induced by transforming growth factor-beta1 ( TGF-beta1 ) in a
Smad dependent manner, the cross-talk of Smad signaling pathway with other signaling pathways still remains poorly understood
Lo et al., Molecular cancer 2010
:
In response to TGFbeta stimulation, LMP1 does not abolish
SMAD phosphorylation but
inhibits p21 protein expression
Yilmaz et al., EMBO J 2011
(Melanoma, Experimental) :
Dlx2 counteracts TGFß induced cell-cycle arrest and apoptosis in mammary epithelial cells by at least two molecular mechanisms : Dlx2 acts as a direct transcriptional repressor of TGFß receptor II ( TGFßRII ) gene expression and reduces canonical,
Smad dependent TGFß signalling and expression of the cell-cycle inhibitor
p21 ( CIP1 ) and increases expression of the mitogenic transcription factor c-Myc
Kim et al., Anticancer Res 2013
(Adenocarcinoma, Bronchiolo-Alveolar...) :
CAF induced EMT led to an increase in motility and a decrease in proliferation of NSCLC cells through
SMAD family number-3 (SMAD3) dependent up-regulation of the growth inhibitory gene
p21 ( CIP1 ) [cyclin dependent kinase inhibitor-1A ( CDKN1A ) ] and a-SMA