Gene interactions and pathways from curated databases and text-mining

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CCND1 — ESR1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of ESR1-KAT2B → CCND1 (increases)
    Evidence: Cyclin D1, a protein frequently overexpressed in breast cancer, has been shown to activate unliganded ER through recruiting p160 coactivators and p/CAF [52-55]. The calcium binding protein calmodulin and the activating enzyme of NEDD8, Uba3, both regulate ER activity by modulating the steady-state level of the receptor [56,57].
  • OpenBEL Selventa BEL large corpus: Complex of ESR1-NCOA1 → CCND1 (increases)
    Evidence: Cyclin D1, a protein frequently overexpressed in breast cancer, has been shown to activate unliganded ER through recruiting p160 coactivators and p/CAF [52-55]. The calcium binding protein calmodulin and the activating enzyme of NEDD8, Uba3, both regulate ER activity by modulating the steady-state level of the receptor [56,57].

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Planas-Silva et al., Cancer Res 1999 (Breast Neoplasms) : Functional activity of ectopically expressed estrogen receptor is not sufficient for estrogen mediated cyclin D1 expression
Planas-Silva et al., Cancer Res 2001 (Breast Neoplasms) : In this study, we evaluated whether high levels of AIB1 enable the estrogen receptor to direct the transcription of cyclin D1
Liu et al., J Biol Chem 2002 : Induction of cyclin D1 gene transcription by estrogen receptor alpha (ERalpha) plays an important role in estrogen mediated proliferation
Balasenthil et al., FEBS Lett 2004 (Breast Neoplasms) : Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells ... Furthermore, ER alpha-S305E , but not mutation of ER alpha-S305 to alanine, enhanced the cyclin D1 promoter activity ... These findings suggest that ER alpha activation at S305 is sufficient to upregulate the expression of cyclin D1 , an ER-regulated gene that is implicated in the progression of breast cancer
Bardin et al., Cancer Res 2004 (Ovarian Neoplasms) : Moreover, ERalpha and ERbeta had opposite actions on cyclin D1 gene regulation, because ERbeta down-regulated cyclin D1 gene expression, whereas ERalpha increased cyclin D1 levels
Kilker et al., J Steroid Biochem Mol Biol 2004 (Breast Neoplasms) : These studies suggest that estrogen receptor mediates cyclin D1 expression and growth of tamoxifen-resistant tumors
Petre-Draviam et al., Oncogene 2005 (Prostatic Neoplasms) : The requirement of this domain for nuclear receptor repression was conserved with respect to thyroid hormone receptor beta-1, whereas cyclin D1 activation of the estrogen receptor occurred independently of the central region
Townson et al., Biochem Biophys Res Commun 2006 : Consequently, we asked whether RFP would modulate ESR1 activity and we discovered that RFP was important for the ESR1 dependent expression of cyclin D1 (CCND1) and the progesterone receptor (PR), but not IRS1 or MYC
Teng et al., Endocr Relat Cancer 2008 (Carcinoma, Transitional Cell...) : Increased expression of ERalpha may contribute to early induction of cyclin D1 and cyclin E during the cell cycle in bladder cancer cells
Ogba et al., Cancer Res 2008 : HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb
Mullany et al., Am J Physiol Gastrointest Liver Physiol 2010 : Previous reports have shown that cyclin D1 can directly enhance estrogen receptor activity and inhibit androgen receptor activity in a ligand independent manner and thus may play an important role in hormone-responsive malignancies
Yang et al., Cancer Res 2010 (Breast Neoplasms) : Here, we show the histone demethylase JMJD2B is regulated by both ERalpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1 , CCNA1, and WEE1
Casimiro et al., Mol Endocrinol 2013 : Although it is known that cyclin D1 regulates estrogen receptor ( ER ) a transactivation using heterologous reporter systems, the in vivo biological significance of cyclin D1 to estrogen dependent signaling, and the molecular mechanisms by which cyclin D1 is involved, are yet to be elucidated
Zwijsen et al., Cell 1997 : CDK independent activation of estrogen receptor by cyclin D1 ... The activation of estrogen receptor by cyclin D1 is not inhibited by anti-estrogens ... A direct physical binding of cyclin D1 to the hormone binding domain of the estrogen receptor results in an increased binding of the receptor to estrogen response element sequences, and upregulates estrogen receptor mediated transcription
Neuman et al., Mol Cell Biol 1997 : We show that ectopic expression of cyclin D1 can stimulate the transcriptional activity of the estrogen receptor in the absence of estradiol and that this activity can be inhibited by 4-hydroxytamoxifen and ICI 182,780 ... Stimulation of the estrogen receptor by cyclin D1 is independent of cyclin dependent kinase 4 activation