Gene interactions and pathways from curated databases and text-mining

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GPR68 — PTGS2

Text-mined interactions from Literome

Shelby et al., Virology journal 2007 : Kaposi 's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells ... To determine whether increased COX-2 expression and PGE2 production is mediated by the angiogenic and tumorigenic KSHV encoded G-protein coupled receptor ( vGPCR ), we developed a recombinant retrovirus to express vGPCR in Human Umbilical Vascular Endothelial Cells ( HUVEC )
Pham et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : Cyclooxygenase-2 (COX-2) is rapidly induced by angiotensin (Ang)-II in the non-tumorigenic, rat intestinal epithelial cell line, IEC-18, through its G-protein coupled receptor , AT1R
Liu et al., Am J Physiol Heart Circ Physiol 2010 : Experiments with knockdown with small interfering RNA specific to OGR1 and specific inhibitors for G proteins showed that acidification induced COX-2 expression, PGI ( 2 ) production, and MKP-1 expression, but not PAI-1 expression and inhibition of proliferation, were dependent on OGR1 and mainly mediated by G ( q/11 ) protein ... In conclusion, acidic pH-induced vascular actions of AoSMCs can be dissected to OGR1 dependent and -independent pathways : COX-2 expression, PGI ( 2 ) production, and MKP-1 expression are mediated by OGR1 , but PAI-1 expression and inhibition of proliferation are not
Haddad et al., J Biol Chem 2012 (Inflammation) : Here we show that the G protein coupled receptor prostaglandin E ( 1 ) ( EP ( 1 ) ) reduces the expression of COX-2 in a concentration dependent manner through a mechanism that does not require receptor activation