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GPR68 — PTGS2
Text-mined interactions from Literome
Shelby et al., Virology journal 2007
:
Kaposi 's sarcoma associated herpesvirus
G-protein coupled receptor activation of
cyclooxygenase-2 in vascular endothelial cells ... To determine whether increased
COX-2 expression and PGE2 production is
mediated by the angiogenic and tumorigenic KSHV encoded
G-protein coupled receptor ( vGPCR ), we developed a recombinant retrovirus to express vGPCR in Human Umbilical Vascular Endothelial Cells ( HUVEC )
Pham et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
Cyclooxygenase-2 (COX-2) is rapidly
induced by angiotensin (Ang)-II in the non-tumorigenic, rat intestinal epithelial cell line, IEC-18, through its
G-protein coupled receptor , AT1R
Liu et al., Am J Physiol Heart Circ Physiol 2010
:
Experiments with knockdown with small interfering RNA specific to OGR1 and specific inhibitors for G proteins showed that acidification induced
COX-2 expression, PGI ( 2 ) production, and MKP-1 expression, but not PAI-1 expression and inhibition of proliferation, were
dependent on
OGR1 and mainly mediated by G ( q/11 ) protein ... In conclusion, acidic pH-induced vascular actions of AoSMCs can be dissected to OGR1 dependent and -independent pathways :
COX-2 expression, PGI ( 2 ) production, and MKP-1 expression are
mediated by
OGR1 , but PAI-1 expression and inhibition of proliferation are not
Haddad et al., J Biol Chem 2012
(Inflammation) :
Here we show that the
G protein coupled receptor prostaglandin E ( 1 ) ( EP ( 1 ) )
reduces the expression of
COX-2 in a concentration dependent manner through a mechanism that does not require receptor activation