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CREB5 — PTGS2

Text-mined interactions from Literome

Ogasawara et al., J Biol Chem 2001 : These data suggest that C/EBP beta, AP-1, and CREB play crucial roles in the shear stress induced cox-2 expression in osteoblasts
Tang et al., Oncogene 2001 : In contrast, treatment with forskolin, an activator of adenylyl cyclase, led to phosphorylation of CREB and ATF-1 and activation of COX-2 promoter
Eliopoulos et al., EMBO J 2002 (Inflammation) : Induction of COX-2 by LPS in macrophages is regulated by Tpl2 dependent CREB activation signals ... The ability of Tpl2 to regulate COX-2 expression depends on ERK signals that activate p90Rsk and Msk1, which in turn phosphorylate CREB , a key regulator of COX-2 transcription
Lee et al., Br J Pharmacol 2003 : The effects of sauchinone on the inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase 2 (COX-2) gene expression and on the activation of transcription factors, nuclear factor-kappaB (NF-kappaB), CCAAT/enhancer binding protein (C/EBP), activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects
Shanmugam et al., Diabetes 2004 : Promoter deletion analyses and inhibition of transcription by NF-kappaB superrepressor and cAMP-responsive element binding ( CREB ) mutants confirmed the involvement of NF-kappaB and CREB transcription factors in high glucose induced COX-2 regulation
Shafer et al., Biochim Biophys Acta 2005 : Anisomycin induces COX-2 mRNA expression through p38 ( MAPK ) and CREB independent of small GTPases in intestinal epithelial cells ... Clostridium difficile toxin B inhibition of small GTPases did not affect anisomycin induced COX-2 mRNA expression or phosphorylation of p38MAPK and CREB but did inhibit sorbitol dependent COX-2 expression and phosphorylation of p38MAPK and CREB
Pino et al., Cancer Biol Ther 2005 (Pancreatic Neoplasms) : Electrophoretic mobility shift assay and chromatin immunoprecipitation assay results further suggested a role for CREB in COX-2 transcriptional control
Pham et al., J Cell Biochem 2006 : CREB dependent cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression is mediated by protein kinase C and calcium ... Expression of a dominant negative CREB ( S133A ) blocked PDB/TG dependent induction of both COX-2 and mPGES-1 promoters ... Decreased CREB expression by siRNA blocked PDB/TG dependent expression of COX-2 and mPGES-1 mRNA
Jang et al., Exp Mol Med 2006 : In young HDFs, CREB phosphorylation decreased following LPA treatment, and both c-fos and COX-2 protein levels increased rapidly
Lee et al., Neurobiol Dis 2007 (Status Epilepticus) : To examine the role of CREB in SE-induced COX-2 expression, we generated a transgenic mouse strain that expresses A-CREB, a potent repressor of CREB dependent transcription
Zhao et al., J Cell Biochem 2007 : Protein kinase Cdelta mediated CREB activation regulates ghrelin induced cyclooxygenase-2 expression and prostaglandin E2 production in human colonic epithelial cells ... In order to examine the involvement of NF-kappaB and cAMP responsive element binding protein ( CREB ) in this response, the NF-kappaB inhibitory protein IkappaBalpha or a dominant negative mutant of CREB was co-transfected into cells and the data show that transfection of either IkappaBalpha or DN-CREB significantly attenuated ghrelin induced COX-2 expression
Jeong et al., Biochem Biophys Res Commun 2007 : Site-specific mutation analyses confirmed that Rd-mediated transcriptional activation of COX-2 gene was regulated by C/EBP and CREB
Pham et al., J Cell Physiol 2008 : Inhibition of CREB expression using two separate RNAi methods blocked COX-2 expression by Ang II and EGF ... Expression of a dominant negative CREB mutant inhibited Ang II- and EGF dependent induction of the COX-2 promoter
Song et al., Gut 2007 (Adenocarcinoma...) : CREB-specific siRNA and DN AP-1 blocked CD and DC-induced COX-2 induction
Wei et al., Biochem Pharmacol 2007 (Adenocarcinoma...) : The role of CREB and NF-kappaB in I-BOP induced COX-2 expression was further explored at the promoter level
Ghosh et al., Neoplasia (New York, N.Y.) 2007 (Prostatic Neoplasms) : We have identified CREB mediated activation of Cox-2 as a potential signaling pathway in prostate cancer which can be blocked with a nontoxic, cost-effective dietary supplement like Nexrutine, demonstrating a prospective for development of Nexrutine for prostate cancer management
Feng et al., Cardiovasc Res 2008 (Disease Models, Animal...) : Isoflurane failed to mobilize cyclooxygenase-2 inducing CREB in ICER overexpressing, remodelled hearts, which was associated with a shortening of the second window of protection
Morris et al., Biochem Biophys Res Commun 2008 : In addition, we also show that changing the fatty acid groups of PC ( e.g. using l-alpha-phosphatidylcholine beta-arachidonoyl-gamma-palmitoyl ( PAPC ) ) has a profound effect on the regulation of COX-2 expression and CREB activation ... This study provides new evidence for the anti-inflammatory activity of DPPC and that this activity is at least in part mediated via CREB activation of COX-2
Sun et al., Cell Signal 2008 (MAP Kinase Signaling System) : Here we report that COX-2 gene promoter mutation studies indicate a role of cAMP response element binding protein ( CREB ) in corticosterone induced COX-2 gene expression
Sirianni et al., J Biol Chem 2009 : In this study, we investigated the role of cyclooxygenase-2 (COX-2) in CREB dependent-aromatase expression in Leydig tumor cells
Jeong et al., J Immunol 2009 (Arthritis, Rheumatoid) : Site directed mutagenesis revealed that Pin1 mediated transcriptional activation of COX-2 was coordinately regulated by NF-kappaB, CREB , and C/EBP
Scoditti et al., Cardiovasc Res 2010 : COX-2 downregulation after siRNA targeting CRE binding protein ( CREB ) confirmed the role of CREB in mediating COX-2 transcription ... VEGF induces CREB mediated COX-2 expression through a PKCalpha dependent pathway in human endothelium
Fossat et al., J Neurosci 2010 (Disease Models, Animal...) : Moreover, spinal nerve ligation animals showed enhanced transcription of the CREB/CRE dependent gene COX-2 ( cyclooxygenase 2 ), which also depends strictly on Ca(V)1.2 activation