Gene interactions and pathways from curated databases and text-mining

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IL4 — SLAMF1

Text-mined interactions from Literome

Morita et al., Scand J Rheumatol 2006 (Arthritis, Rheumatoid) : In vitro modulation of the cytokine network by MTX, IFN-gamma, and IL-4 is one of the major targets for MTX, and production of IFN-gamma and IL-4 by PBMCs may be suppressed by SLAM on activated CD4+ T-cell in patients with RA
Yusuf et al., J Immunol 2010 : We further demonstrate that SLAM ( Slamf1, CD150 ), a surface receptor that uses SAP signaling, is specifically required for IL-4 production by GC T ( FH ) cells
Cannons et al., J Immunol 2010 : Overexpression of SAP in T cells increased and sustained PKC-theta recruitment to the immune synapse and elevated IL-4 production in response to TCR plus SLAM mediated stimulation ... Moreover, PKC-theta, like SAP, was required for SLAM mediated increases in IL-4 production, and, conversely, membrane targeted PKC-theta mutants rescued IL-4 expression in SAP ( -/- ) CD4 ( + ) T cells, providing genetic evidence that PKC-theta is a critical component of SLAM/SAP mediated pathways that influence TCR-driven IL-4 production