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IL4 — SLAMF1
Text-mined interactions from Literome
Morita et al., Scand J Rheumatol 2006
(Arthritis, Rheumatoid) :
In vitro modulation of the cytokine network by MTX, IFN-gamma, and
IL-4 is one of the major targets for MTX, and production of IFN-gamma and IL-4 by PBMCs may be
suppressed by
SLAM on activated CD4+ T-cell in patients with RA
Yusuf et al., J Immunol 2010
:
We further demonstrate that
SLAM ( Slamf1, CD150 ), a surface receptor that uses SAP signaling, is specifically
required for
IL-4 production by GC T ( FH ) cells
Cannons et al., J Immunol 2010
:
Overexpression of SAP in T cells increased and sustained PKC-theta recruitment to the immune synapse and elevated
IL-4 production in
response to TCR plus
SLAM mediated stimulation ... Moreover, PKC-theta, like SAP, was required for
SLAM mediated increases in
IL-4 production, and, conversely, membrane targeted PKC-theta mutants rescued IL-4 expression in SAP ( -/- ) CD4 ( + ) T cells, providing genetic evidence that PKC-theta is a critical component of SLAM/SAP mediated pathways that influence TCR-driven IL-4 production