Gene interactions and pathways from curated databases and text-mining

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IL4 — MMP12

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Lee et al., J Allergy Clin Immunol 2003 (Asthma...) : These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta, IL-4 , and TNF-alpha expression
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Yang et al., Arthritis Rheum 2005 (Arthritis, Experimental...) : These data demonstrate the requirement of PAR-1 for the expression of AIA, the development of an antigen-specific Ig response, thrombin induced macrophage cytokine and MMP expression, and the inhibitory effect of PAR-1 on serum IL-4
Shimizu et al., Trends Cardiovasc Med 2005 (Aortic Aneurysm) : A Th2 cytokine milieu was shown to increase selected matrix metalloproteinase ( MMP ) expression, and interleukin 4 stimulated macrophage production of elastolytic matrix metalloproteinase 12 in vitro
Nelson et al., Am J Physiol Lung Cell Mol Physiol 2012 (Pneumonia, Pneumocystis) : IL-4 treatment induced the 54-kDa proenzyme form of MMP12 and the 22-kDa fully processed and active form, whereas IFN-? failed to induce either