◀ Back to IL4
IL4 — IRS1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IRS1
→
IL4
(increases)
Fantin et al., J Biol Chem 1998
Evidence: epidermal growth factor and interleukin-4 elicit tyrosine phosphorylation of IRS1
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IRS1 (IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IRS1 (IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: assay, physical interaction, other species
Text-mined interactions from Literome
Gingras et al., Mol Endocrinol 2000
(Breast Neoplasms) :
IL-4 rapidly
induced IRS-1 and IRS-2 phosphorylation in ZR-75-1 human breast cancer cell lines
Gingras et al., J Steroid Biochem Mol Biol 2001
:
We have also found that
IL-4 rapidly
induced IRS-1 and IRS-2 phosphorylation in these cell lines
Zamorano et al., Int Immunol 2001
:
Moreover, TNF-alpha had no effect on the activation of
IRS-1 induced by
IL-4
Prokopchuk et al., Br J Cancer 2005
(Pancreatic Neoplasms) :
Interleukin-4 enhanced activity of MAPK, Akt-1, and Stat3 in IL-4-responsive, but not in IL-4-unresponsive MIA PaCa-2 cells ; however,
IL-4 enhanced tyrosine phosphorylation of
insulin receptor substrate-1 and -2 in all cell lines
Kim et al., J Biol Chem 2005
(Inflammation) :
In addition, using a phospho-specific antibody against IRS-1 phosphorylated at Ser ( 24 ), we found that
interleukin-1 or TNF-alpha treatment of Fao cells
stimulated increased phosphorylation of endogenous
IRS-1 at Ser ( 24 )
Wang et al., Blood 1995
:
These results indicate that IL-13 does not use the IL-2R gamma subunit in its receptor complex and that expression of IL-2R gamma enhances, but is not absolutely required for mediating
IL-4 induced tyrosine phosphorylation of
IRS-1/4PS
Johnston et al., J Biol Chem 1995
:
We report here that IL-2, IL-7, and IL-15, as well as
IL-4 , rapidly
stimulate the tyrosine phosphorylation of
IRS-1 and IRS-2 in human peripheral blood T cells, NK cells, and in lymphoid cell lines ... We further demonstrate that the p85 subunit of phosphoinositol 3-kinase associates with
IRS-1 in
response to IL-2 and
IL-4 in T cells
Keegan et al., Cell 1994
:
An IL-4 receptor region containing an insulin receptor motif is important for
IL-4 mediated
IRS-1 phosphorylation and cell growth
Russell et al., Science 1993
(Severe Combined Immunodeficiency) :
IL-2R gamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross linking data, the ability of IL-2R gamma to augment IL-4 binding affinity, and the requirement for IL-2R gamma in
IL-4 mediated phosphorylation of
insulin receptor substrate-1
Wang et al., Science 1993
:
Insulin and
IL-4 sensitivity was
restored to 32D cells by expression of
IRS-1 , the principal substrate of the insulin receptor
Burfoot et al., J Biol Chem 1997
:
Janus kinase dependent activation of
insulin receptor substrate 1 in
response to
interleukin-4 , oncostatin M, and the interferons ... In addition to a role in response to insulin and insulin-like growth factors,
insulin receptor substrate 1 (IRS-1) is phosphorylated in
response to
IL-4 , the interferons ( IFNs ) and oncostatin M (OSM) ... In contrast, phosphorylation of
IRS-1 mediated by the Type I IFNs,
IL-4 , and OSM is JAK dependent