Gene interactions and pathways from curated databases and text-mining

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AKAP9 — PRKAR2B

Pathways - manually collected, often from reviews:

  • BioCarta protein kinase a at the centrosome: PKAc/RII-alpha complex (PRKACB-PRKACG-PRKAG1-PRKAR2A) → RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PKAc/RII-alpha complex (PRKACB-PRKACG-PRKAG1-PRKAR2A) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) → CDK1 (CDC2) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PP2A (PPP2R5D) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PPP1CA → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: AKAP350 (AKAP9) → PKAc/RII-alpha/RII-beta complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: AKAP350 (AKAP9) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PRKCL1 (PKN1) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PKAc/RII-alpha/RII-beta complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • BioCarta protein kinase a at the centrosome: PKC-epsilon (PRKCE) → PKAc/RII-alpha/RII-beta/PKN/PPP1CA/PKC-epsilon/PP2A/AKAP350 complex (PRKACB-PRKACG-PRKAG1-PRKAR2A-PRKAR2B-PKN1-PPP1CA-PRKCE-PPP2R5D-AKAP9) (modification, collaborate)
  • Reactome Reaction: AKAP9 → PRKAR2B (reaction) Jang et al., J Biol Chem 2002, Hirota et al., Cell 2003, Seki et al., Science 2008, Macůrek et al., Nature 2008
  • Reactome Reaction: AKAP9 → PRKAR2B (direct_complex) Casenghi et al., Dev Cell 2003

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lacey et al., Proc Natl Acad Sci U S A 1999 : Cyclin dependent kinase control of centrosome duplication
Tsakraklides et al., J Cell Sci 1999 (Melanoma, Experimental) : Evidence is also presented that the globular tail of myosin-Va, but not myosin-Vb , targets this motor molecule to the centrosome as confirmed by colocalization in cells stained with antibodies to ( gamma)-tubulin
Carr et al., Biochem J 1999 : These results suggest that altered PKA-AKAP interactions may contribute to the distinct responses of PA and PO follicles to high levels of cAMP, and that higher cAMP levels are required to activate PKA in PO ovaries
Sun et al., J Biol Chem 2000 : Phosphorylation reactions mediated by CFTR associated PKA II are inhibited by Ht31 peptide but not by the control peptide Ht31P, indicating that a protein kinase A anchoring protein ( AKAP ) is responsible for the association between PKA and CFTR
Zakhary et al., J Biol Chem 2000 : PKA stimulation of intact Chinese hamster ovary cells increased RIIalpha binding to AKAP100/mAKAP and AKAP15/18 by approximately 7- and 82-fold, respectively
Niu et al., Curr Biol 2001 : Finally, AKAP110 significantly potentiated G alpha 13-induced activation of PKA
Rappleye et al., Dev Cell 2002 : The APC is also required for tight cortical association and posterior movement of the paternal pronucleus and its associated centrosome
Liu et al., Proc Natl Acad Sci U S A 2002 : Plks have been reported to mediate multiple mitotic processes, including bipolar spindle formation, activation of Cdc25C, actin ring formation, centrosome maturation, and activation of the anaphase promoting complex ... Plks have been reported to mediate multiple mitotic processes, including bipolar spindle formation, activation of Cdc25C , actin ring formation, centrosome maturation, and activation of the anaphase promoting complex
Brown et al., Biol Reprod 2002 : By compartmentalizing PKA, AKAP140 and/or other AKAPs could spatially regulate PKA activity during oocyte development
Affaitati et al., J Biol Chem 2003 : Here we show that conditional expression of AKAP121 in PC12 cells selectively enhances cAMP.PKA signaling to mitochondria
Metge et al., J Biol Chem 2004 : Investigation into the role of Stat3 signaling during centrosome production demonstrated that Stat3 does not directly regulate the transcription of the centrosome genes encoding gamma-tubulin and PCM-1
Krämer et al., Nat Cell Biol 2004 : Chemical inhibition of Chk1 resulted in premature centrosome separation and activation of centrosome associated Cdk1
Nelsen et al., J Biol Chem 2005 (Aneuploidy...) : Transient transfection of cyclin D1 also induced centrosome and mitotic spindle abnormalities in breast epithelial cells, suggesting that this may be a generalized effect
Ye et al., Chin J Cancer 2005 (Aneuploidy...) : Abnormal centrosome can cause multipolar spindle formation, chromosome mis-segregation , and unequal distribution, and finally leads to cancers
Casenghi et al., J Cell Sci 2005 : Our data also indicate that dynactin is required for the targeting of Nlp and ninein to the centrosome
Haren et al., J Cell Biol 2006 : In contrast, NEDD1 can target to the centrosome in the absence of gamma-tubulin ... In contrast, NEDD1 can target to the centrosome in the absence of gamma-tubulin
Sankaran et al., Cancer Res 2006 : In the present study, ( a ) we confirmed that the ubiquitination activity of BRCA1 regulates centrosome number and function in Hs578T breast cancer cells ; ( b ) we observed that both the amino and carboxyl termini of BRCA1 are required for regulation of centrosome function in vitro ; ( c ) an internal domain ( 770-1,290 ) is dispensable for centrosome regulation ; ( d ) BARD1 is required for regulation of centrosome function and protein sequences within the terminal 485 amino acids are necessary for activity ; and ( e ) BARD1 is localized at the centrosome throughout the cell cycle
Chen et al., Eur J Cell Biol 2006 : We have found that the functional regulation of the I ( Ks ) channel by PKA requires the A kinase anchoring protein ( AKAP ) Yotiao
Naoe et al., Cancer Sci 2006 (Hematologic Neoplasms...) : Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53
Bergstralh et al., Exp Cell Res 2007 (Lung Neoplasms) : Mass spectroscopy identified the protein as nucleophosmin/B23 (NPM), a multifunctional protein with diverse roles : ribosome biosynthesis, p53 regulation , nuclear-cytoplasmic shuttling, and centrosome duplication
Landen et al., Clin Cancer Res 2007 (Ovarian Neoplasms) : To assess the clinical significance of Aurora-A kinase, a centrosome regulating serine-threonine kinase , in ovarian carcinoma
Salpingidou et al., J Cell Biol 2007 : A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane
Tamai et al., Genes Cells 2007 : Our results suggest the possibility that Pax6 regulates the INM by stabilizing the centrosome at the apical side
Kfoury et al., Oncogene 2008 : These observations highlight an unsuspected link between Tax induced IKK activation and the centrosome
Gomez-Ferreria et al., Curr Biol 2007 : Human Cep192 is required for mitotic centrosome and spindle assembly
Kodani et al., Mol Biol Cell 2008 : The Golgi protein GM130 regulates centrosome morphology and function
Sankaran et al., Cancer Res 2007 : We show that Aurora-A kinase modulates the BRCA1 inhibition of centrosome function by decreasing the E3 ubiquitin ligase activity of BRCA1
Plo et al., Blood 2008 (Myeloproliferative Disorders...) : Moreover, JAK2 activation increased centrosome and ploidy abnormalities
Bisel et al., J Cell Biol 2008 : ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65
Lawo et al., Curr Biol 2009 : HAUS , the 8-subunit human Augmin complex, regulates centrosome and spindle integrity
Zhang et al., J Cell Sci 2009 : Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome
Jeske et al., Pain 2009 (Calcium Signaling) : Recent studies have reported that the A-kinase Anchoring Protein 150 ( AKAP150 ) mediates PKA phosphorylation of TRPV1 in several nociceptive models
Bourke et al., Oncogene 2010 : Cdk2 controls normal centrosome duplication, but Chk1 dependent centrosome amplification also occurs after DNA damage
Gonçalves et al., EMBO Rep 2010 : TBCCD1 , a new centrosomal protein, is required for centrosome and Golgi apparatus positioning
Colello et al., J Cell Sci 2010 : Androgen and Src signaling regulate centrosome activity
Morita et al., Proc Natl Acad Sci U S A 2010 : Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance
Inaba et al., PloS one 2010 : E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells
Christian et al., J Biol Chem 2011 (Chronic Disease...) : Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes
Wakida et al., PloS one 2010 (Osteosarcoma) : In this study we ablate the centrosome by intracellular laser irradiation to understand the role of the centrosome in two vastly different cell types, human osteosarcoma ( U2OS ) and rat kangaroo kidney epithelial cells ( PtK )
Smith et al., EMBO J 2011 : Conversely, MT stabilization in mitosis slows down Cdk1 dependent centrosome movement
Chen et al., Cell Res 2012 : Mechanistically, SNX10 interacts with V-ATPase complex and targets it to the centrosome where ciliogenesis is initiated ... Mechanistically, SNX10 interacts with V-ATPase complex and targets it to the centrosome where ciliogenesis is initiated
Ferraro et al., J Cell Sci 2011 : By analyzing Apaf1 depleted cells, we have found that Apaf1 loss induces centrosome defects that impair centrosomal microtubule nucleation and cytoskeleton organization
Colello et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Integrins regulate microtubule nucleating activity of centrosome through mitogen activated protein kinase/extracellular signal regulated kinase kinase/extracellular signal regulated kinase ( MEK/ERK ) signaling
Heng et al., J Cell Sci 2012 : Instead, we find that LIMK2 acts through TPPP in the regulation of astral microtubule organization, whereas both LIMK1 and LIMK2 affect centrosome focusing ... Instead, we find that LIMK2 acts through TPPP in the regulation of astral microtubule organization, whereas both LIMK1 and LIMK2 affect centrosome focusing
Ikeda et al., J Biol Chem 2012 : Depletion of Fry causes centrosome and centriole splitting in mitotic spindles and reduces the kinase activity of Plk1 in mitotic cells and the accumulation of Thr-210 phosphorylated Plk1 at the spindle poles
Andersen et al., Development 2012 : In addition, we show that centrosome position and motility are regulated by LIM homeodomain transcription factor activity, which is specifically required for the development of RB peripheral axons
Sekiguchi et al., Br J Pharmacol 2013 (Hyperalgesia) : In NG108-15 cells and/or rat DRG neurons, dibutyryl cAMP ( db-cAMP ) or PGE ( 2 ) increased T currents, an effect blocked by AKAP St-Ht31 inhibitor peptide ( AKAPI ) or KT5720, a PKA inhibitor
Li et al., Mol Oncol 2013 : In this study we report that expression of glioma pathogenesis related protein 1 ( GLIPR1 ) regulated numerous apoptotic, cell cycle, and spindle/centrosome assembly related genes, including AURKA and TPX2, and induced apoptosis and/or mitotic catastrophe ( MC ) in prostate cancer ( PCa ) cells, including p53 mutated/deleted, androgen-insensitive metastatic PCa cells
Dacher et al., J Neurosci 2013 : Using immunofluorescence and whole-cell patch-clamp recording in rat midbrain slices, we show that activation of postsynaptic D ( 2 ) -like family of dopamine ( DA ) receptor in the ventral tegmental area ( VTA ) induces long-term depression ( LTD ) of GABAergic synapses on DA neurons through an inositol triphosphate receptor mediated local rise in postsynaptic Ca ( 2+ ) and CaN activation accompanied by PKA inhibition, which requires AKAP150 as a bridging signaling molecule
Leonard et al., Cell cycle (Georgetown, Tex.) 2013 : Inhibition of Akt activation with MK2206 reduced the whole-cell and centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes
Sonnen et al., J Cell Sci 2013 : We demonstrate that Cep192 plays a key role in centrosome recruitment of both Cep152 and Plk4
Félix et al., J Cell Biol 1994 : This suggests that gamma-tubulin and/or associated molecules play a key role in centrosome formation and activity
Nakamura et al., J Cell Biol 1998 : These results provide evidence that the Ran binding protein, RanBPM, is involved in microtubule nucleation, thereby suggesting that Ran regulates the centrosome through RanBPM
Arnaud et al., Chromosoma 1998 : In vertebrates, Plks participate in centrosome maturation and spindle assembly, as well as the activation of the Cdk1/cyclin B complex ... In vertebrates, Plks participate in centrosome maturation and spindle assembly, as well as the activation of the Cdk1/cyclin B complex
Mantel et al., Blood 1999 (Polyploidy) : p53 has already been implicated in centrosome regulation