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BRCA1 — MYLIP

Text-mined interactions from Literome

Moskwa et al., Mol Cell 2011 : Antagonizing miR-182 enhances BRCA1 protein levels and protects them from IR-induced cell death, while overexpressing miR-182 reduces BRCA1 protein, impairs homologous recombination mediated repair, and render cells hypersensitive to IR ... Conversely, antagonizing miR-182 enhances BRCA1 levels and induces resistance to PARP1 inhibitor ... Together these results suggest that miR-182 mediated downregulation of BRCA1 impedes DNA repair and may impact breast cancer therapy
Chang et al., Nat Med 2011 : Mechanistically, we found that BRCA1 epigenetically represses miR-155 expression via its association with HDAC2, which deacetylates histones H2A and H3 on the miR-155 promoter
Li et al., Toxicological sciences : an official journal of the Society of Toxicology 2012 (Carcinoma, Non-Small-Cell Lung...) : In summary, we suggest that miR-638 is involved in the BaP induced carcinogenesis by targeting BRCA1