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ERBB2 — JAK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ERBB2 → JAK2 (directlyIncreases, ERBB2 Activity)
  Evidence: Our results indicate that autocrine secretion of PRL stimulates tyrosine phosphorylation of ErbB-2 by Jak2, provides docking sites for Grb2 and stimulates Ras-MAP kinase cascade, thereby causing unrestricted cellular proliferation.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: JAK2 — ERBB2 (physical association, affinity chromatography technology) Ren et al., J Biol Chem 2002
• IRef Hprd Interaction: JAK2 — ERBB2 (in vivo) Ren et al., J Biol Chem 2002
• IRef Intact Interaction: Complex of ERBB2-SRC-SRC-JAK2-ERBB2-JAK2 (association, anti bait coimmunoprecipitation) Liang et al., Cancer Cell 2010*
• IRef Ophid Interaction: ERBB2 — JAK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ERBB2 — JAK2 (aggregation, confirmational text mining) Ren et al., J Biol Chem 2002