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HES1 — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: TP53 → HES1 (transcriptional regulation, unknown) Wei et al., Cell 2006
  Evidence: DNABINDING

Text-mined interactions from Literome

Huang et al., Proc Natl Acad Sci U S A 2004 (Cell Transformation, Neoplastic) : HES1 , HEY1, and TFAP4, which are members of the basic helix-loop-helix transcription family, and OSR1 were shown to activate p53 through repression of HDM2 transcription
Kannan et al., J Exp Med 2013 (Leukemia, Myeloid, Acute) : Induced activation through any of the Notch receptors ( Notch1-4 ), or through the Notch target Hairy/Enhancer of Split 1 (HES1) , consistently leads to AML growth arrest and caspase dependent apoptosis, which are associated with B cell lymphoma 2 (BCL2) loss and enhanced p53/p21 expression