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IFNB1 — PIK3CA
Text-mined interactions from Literome
Molnarfi et al., J Immunol 2005
:
The use of cycloheximide and actinomycin D shows that sIL-1Ra was an immediate early gene
induced by
IFN-beta and that
PI3K was controlling sIL-1Ra gene transcription
Aksoy et al., Eur J Immunol 2005
:
Here, we investigated the consequences of pharmacological inhibition of
PI3K on Toll-IL-1 receptor domain containing adapter inducing IFN-beta ( TRIF ) -dependent signaling, which
induces IFN-beta gene expression downstream of TLR3 and TLR4 ... Experiments carried out in HEK 293T cells stably expressing TLR3 or TLR4 confirmed that inhibition of
PI3K activity
enhances NF-kappaB dependent promoters as well as
IFN-beta promoter activities without interfering with transcription at the positive regulatory domain III-I ... We conclude that inhibition of
PI3K activity enhances TRIF dependent NF-kappaB activity, and thereby
increases IFN-beta synthesis elicited by TLR3 or TLR4 ligands