◀ Back to IFNG

CXCR3 — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCR3 → IFNG (increases, IFNG Activity)
  Evidence: the CXC chemokines Mig and interferon-? inducible protein 10 can be expressed and bound by endothelium stimulated with interferon-? and tumor necrosis factor (TNF) ?, and can induce the firm adhesion of T lymphocyte in shear flow via CXCR3.

Text-mined interactions from Literome

Nakajima et al., Eur J Immunol 2002 : In contrast, CXCR3 was induced on STAT4-deficient T cells independently of IL-12 stimulation as long as IFN-gamma was produced as a result of potent TCR stimulation
Hildebrandt et al., J Immunol 2004 (Pneumonia) : CXCR3 is a chemokine receptor that is expressed on activated Th1/Tc1 T cell subsets and the expression of its ligands CXCL9 ( monokine induced by IFN-gamma (Mig) ) and CXCL10 ( IFN-gamma-inducible protein 10 ( IP-10 ) ) can be induced in a variety of cell types by IFN-gamma alone or in combination with TNF-alpha
Sarween et al., J Immunol 2004 (Diabetes Mellitus...) : This is associated with a failure of CD4 cells to differentiate into effector cells and to up-regulate the IFN-gamma dependent chemokine receptor CXCR-3 , which confers the ability to respond to pancreatic islet derived CXCL10
Muehlinghaus et al., Blood 2005 : These results show that lack of CXCR4 expression on plasma-cell precursors is not a limiting factor for plasma-cell homing and that the expression of CXCR3 on memory B cells and plasma-cell precursors is induced by IFN-gamma , provided in human T helper type 1 ( Th1 ) -biased immune responses
Zhu et al., J Pharmacol Exp Ther 2006 (Encephalomyelitis, Autoimmune, Experimental) : Periplocoside E inhibits experimental allergic encephalomyelitis by suppressing interleukin 12-dependent CCR5 expression and interferon-gamma dependent CXCR3 expression in T lymphocytes ... In vitro study also showed PSE inhibited interferon (IFN)-gamma dependent CXCR3 expression in T cells through suppressing T-cell receptor ( TCR ) ligation induced IFN-gamma production, whereas it inhibited interleukin (IL)-12 dependent CCR5 expression through suppressing IL-12 reactivity in TCR triggered T cells
Hirota et al., J Immunol 2006 : In the present study, we explored expression and possible functions of CXCL11, a CXC chemokine strongly induced by IFN-gamma , and its receptor CXCR3 in the human endometrium
Barbi et al., J Immunol 2008 (Genetic Predisposition to Disease...) : Impaired induction of CXCR3 on BALB/c T cells was not due to lack of IFN-gamma and was mediated partially by IL-10 but not IL-4 or IL-13
Schmitz et al., Brain Behav Immun 2013 : Oppositely, CXCR3-deficiency had no protective effect after traumatic nerve injury but reduced EAE evoked hyperalgesia and was associated with reduced clinical EAE scores, a reduction of the pro-inflammatory cell infiltration and reduced upregulation of interferon gamma and interleukin-17 in the spinal cord