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FGF8 — WNT4
Text-mined interactions from Literome
Wilson et al., Nature 2001
:
Continual
Wnt signalling
blocks the response of epiblast cells to
FGF signals, permitting the expression and signalling of BMP to direct an epidermal fate
Treichel et al., Genes Dev 2003
:
We present evidence that mBtd is required during early limb development to maintain, but not to initiate
Wnt/beta-catenin dependent
FGF , Shh, and BMP mediated signaling
Wu et al., Dev Biol 2005
:
In addition,
Wnt signaling
induces neural crest when its posteriorizing activity is blocked by inhibition of
FGF signaling in neuralized explants
Katoh et al., Int J Mol Med 2006
:
WNT signaling activation in progenitor cells
leads to the growth regulation of progenitor cells themselves through SPRY4 induction, and also to the growth stimulation of proliferating cells through
FGF secretion
Canning et al., Dev Biol 2007
:
The mechanism by which
Wnt signaling
regulates isthmic
Fgf8 expression is likely to be a maintenance response rather than an inductive effect
Olivera-Martinez et al., Development 2007
:
FGF promotes
Wnt8c expression, which persists in the neuroepithelium as FGF signalling declines
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
WNT-beta-catenin-TCF/LEF signaling
induces upregulation of MYC, CCND1, WISP1,
FGF20 , JAG1 and DKK1 genes
Falk et al., Cell stem cell 2008
:
Consistent with this phenotype, self-renewal of mutant neuroepithelial stem cells is enhanced in the
presence of
FGF and requires
Wnt signaling ... In the midbrain, but not in the forebrain, Tgfbr2 ablation results in ectopic expression of Wnt1/beta-catenin and
FGF8 ,
activation of
Wnt target genes, and increased proliferation and horizontal expansion of neuroepithelial cells due to shortened cell-cycle length and decreased cell-cycle exit
Ambrosetti et al., Mol Cell Biol 2008
:
To analyze the
effect of
FGF on
Wnt signaling in osteoblasts, we created reporter cell lines where a Wnt-responsive promoter drives luciferase expression and showed that Wnt3a induced luciferase expression was specifically inhibited by FGF treatment
Yin et al., Dev Biol 2008
:
Here we have identified a robust regulatory network in which mesenchymal
FGF signaling
regulates beta-Catenin mediated
WNT signaling in lung mesenchyme
Hong et al., Development 2008
:
Fgf8a induces neural crest indirectly through the activation of
Wnt8 in the paraxial mesoderm ... Consistent with these observations,
Fgf8a is a potent inducer of Wnt8 in both whole embryos and animal explants, and Fgf8a knockdown
results in a dramatic loss of
Wnt8 expression in the mesoderm ... We propose that
Fgf8a induces NC indirectly through the activation of
Wnt8 in the paraxial mesoderm, which in turn promotes NC formation in the overlying ectoderm primed by Bmp antagonists
Huang et al., Development 2009
:
FGF signaling also
promoted the expression of the Wnt antagonist Sfrp1 and suppressed
Wnt signaling in the prospective eyelid epithelial cells, independently of BMP function
Miyagawa et al., Development 2009
:
The current data also suggest that
Wnt/beta-catenin regulates
Fgf8 expression via Lef/Tcf binding sites in a 3 ' conserved enhancer
Quarto et al., J Bone Miner Res 2010
:
Moreover, fibroblast growth factor 2 (FGF-2) treatment induces phosphorylation of GSK-3beta and increases the nuclear levels of beta-catenin in osteoblasts, suggesting that enhanced activation of
Wnt signaling might be
mediated by
FGF
Villacorte et al., Biochem Biophys Res Commun 2010
:
We also demonstrated that
Wnt/beta-catenin signaling in the ectoderm can positively
regulate Fgf8 possibly antagonizing the epithelial derived Bmp signaling
Aman et al., Dev Biol 2011
:
We have previously shown that
Wnt/ß-catenin signaling
induces Fgf signaling and that interactions between these two pathways regulate primordium migration and prosensory organ formation
Paek et al., Dev Dyn 2012
:
These results, together with previous ones demonstrating that increased
WNT signaling in the anterior neural plate
increases FGF expression, suggest that the levels of WNT and FGF signaling regulate telencephalic versus mid-hindbrain fates
van der Velden et al., Development 2012
:
Exogenous application of FGF4, as well as enhanced
stimulation of
Fgf signaling by overactivated
Wnt signaling in apc mutants, partially restores the fin developmental program
Matsuda et al., Development 2013
(Wnt Signaling Pathway) :
FGF receptor signaling, in turn,
inhibits Wnt signaling
Minor et al., Development 2013
:
FGF signaling
regulates Wnt ligand expression to control vulval cell lineage polarity in C. elegans