Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RHOQ
→
IGF1R
(increases, IGF1R Activity, RHOQ Activity)
Evidence: Translocation of phosphorylated Cbl recruits the adapter protein CrkII to the lipid raft via interaction of the SH2 domain of CrkII with phospho-Cbl51. CrkII also forms a constitutive complex with the guanyl nucleotide-exchange protein C3G. Once translocated into lipid rafts, C3G comes into proximity with the G protein TC10, and catalyses the exchange of GTP for GDP, resulting in the activation of the protein51.