◀ Back to CTNNB1
CTNNB1 — TCF7L2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TCF7L2
→
Complex of CTNNB1-TCF7L2
(directlyIncreases, CTNNB1/TCF7L2 Activity)
Evidence: hTcf-4 transactivates transcription only when associated with beta-catenin.
-
KEGG Wnt signaling pathway:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Adherens junction:
LEF1/TCF7/TCF7L1/TCF7L2
→
CTNNB1
(protein-protein, binding/association)
-
KEGG Melanogenesis:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Pathways in cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Colorectal cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Colorectal cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Endometrial cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Prostate cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Thyroid cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Basal cell carcinoma:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Arrhythmogenic right ventricular cardiomyopathy (ARVC):
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TRRAP (TRRAP)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
SCF complex (BTRC-SKP1-CUL1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TRRAP (TRRAP)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
SCF complex (BTRC-SKP1-CUL1)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
brachyury (T)
(transcription, activates)
Wöhrle et al., Mol Cell Biol 2007*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/Cbp complex (TCF7L2-CTNNB1-ADCY7)
→
Survivin (INCENP)
(transcription, activates)
Ma et al., Oncogene 2005
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4E/TLE4 complex (TCF7L2-TLE4)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Hecht et al., J Biol Chem 2003*, Böhm et al., Biochem Biophys Res Commun 2006*, Weise et al., Nucleic Acids Res 2010, Van de Wetering et al., Mol Cell Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Hecht et al., J Biol Chem 2003*, Böhm et al., Biochem Biophys Res Commun 2006*, Weise et al., Nucleic Acids Res 2010, Van de Wetering et al., Mol Cell Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE4 (TLE4)
→
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Hecht et al., J Biol Chem 2003*, Böhm et al., Biochem Biophys Res Commun 2006*, Weise et al., Nucleic Acids Res 2010, Van de Wetering et al., Mol Cell Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4E/TLE4 complex (TCF7L2-TLE4)
→
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Hecht et al., J Biol Chem 2003*, Böhm et al., Biochem Biophys Res Commun 2006*, Weise et al., Nucleic Acids Res 2010, Van de Wetering et al., Mol Cell Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
HBP1 (HBP1)
(modification, collaborate)
Sampson et al., EMBO J 2001*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/HBP1 complex (TCF7L2-CTNNB1-HBP1)
(modification, collaborate)
Sampson et al., EMBO J 2001*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
HBP1 (HBP1)
→
TCF4/beta catenin/HBP1 complex (TCF7L2-CTNNB1-HBP1)
(modification, collaborate)
Sampson et al., EMBO J 2001*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
Cbp (ADCY7)
(modification, collaborate)
Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/Cbp complex (TCF7L2-CTNNB1-ADCY7)
(modification, collaborate)
Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
Cbp (ADCY7)
→
TCF4/beta catenin/Cbp complex (TCF7L2-CTNNB1-ADCY7)
(modification, collaborate)
Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
ZCCHC12 (ZCCHC12)
(transcription, activates)
Mahmoudi et al., EMBO J 2009*, Sue Ng et al., Biol Chem 2010
Evidence: reporter gene
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF1 (TCF7)
(transcription, activates)
Roose et al., Science 1999*
Evidence: mutant phenotype, assay, reporter gene
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
beta catenin (CTNNB1)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
HDAC1-HDAC2 (HDAC1/HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/HDAC1-HDAC2 complex (TCF7L2-HDAC1_HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4/HDAC1-HDAC2 complex (TCF7L2-HDAC1_HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4/TLE4 complex (TCF7L2-TLE4)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/TLE4 complex (TCF7L2-TLE4)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TLE4 (TLE4)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4 (TCF7L2)
(modification, collaborate)
Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
beta catenin/AR/T-DHT/TIF2 complex (CTNNB1-AR-NCOA2)
(modification, collaborate)
Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
AR/T-DHT complex (AR)
(modification, collaborate)
Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TIF2 (NCOA2)
(modification, collaborate)
Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4 (TCF7L2)
→
beta catenin/AR/T-DHT/TIF2 complex (CTNNB1-AR-NCOA2)
(modification, collaborate)
Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
p300 (EP300)
→
TCF4E/beta catenin/p300 complex (TCF7L2-CTNNB1-EP300)
(modification, collaborate)
Hecht et al., J Biol Chem 2003*, Weise et al., Nucleic Acids Res 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
p300 (EP300)
→
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Hecht et al., J Biol Chem 2003*, Weise et al., Nucleic Acids Res 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4E/beta catenin/p300 complex (TCF7L2-CTNNB1-EP300)
→
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Hecht et al., J Biol Chem 2003*, Weise et al., Nucleic Acids Res 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
BCL9 (BCL9)
→
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Sampietro et al., Mol Cell 2006, Sustmann et al., Mol Cell Biol 2008, Brack et al., Dev Biol 2009*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
BCL9 (BCL9)
→
TCF4E/beta catenin/BCL9 complex (TCF7L2-CTNNB1-BCL9)
(modification, collaborate)
Sampietro et al., Mol Cell 2006, Sustmann et al., Mol Cell Biol 2008, Brack et al., Dev Biol 2009*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4E/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4E/beta catenin/BCL9 complex (TCF7L2-CTNNB1-BCL9)
(modification, collaborate)
Sampietro et al., Mol Cell 2006, Sustmann et al., Mol Cell Biol 2008, Brack et al., Dev Biol 2009*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
→
MYC (MYC)
(transcription, activates)
Gan et al., J Cell Biol 2008
Evidence: reporter gene, physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
beta catenin (CTNNB1)
→
TCF4 (TCF7L2)
(modification, collaborate)
Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
beta catenin (CTNNB1)
→
JUN/FOS/TCF4/beta catenin complex (FOS-JUN-TCF7L2-CTNNB1)
(modification, collaborate)
Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
TCF4 (TCF7L2)
→
JUN/FOS/TCF4/beta catenin complex (FOS-JUN-TCF7L2-CTNNB1)
(modification, collaborate)
Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN/FOS complex (FOS-JUN)
→
JUN/FOS/TCF4/beta catenin complex (FOS-JUN-TCF7L2-CTNNB1)
(modification, collaborate)
Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TNIK (TNIK)
(modification, collaborate)
Mahmoudi et al., EMBO J 2009*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/TNIK complex (TCF7L2-CTNNB1-TNIK)
(modification, collaborate)
Mahmoudi et al., EMBO J 2009*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TNIK (TNIK)
→
TCF4/beta catenin/TNIK complex (TCF7L2-CTNNB1-TNIK)
(modification, collaborate)
Mahmoudi et al., EMBO J 2009*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
CRDBP (IGF2BP1)
(transcription, activates)
Spiegelman et al., Mol Cell 2000*, Noubissi et al., Nature 2006*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
IL8 (CXCL8)
(transcription, activates)
Lévy et al., J Biol Chem 2002*
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
DKK1 (DKK1)
(transcription, activates)
Niida et al., Oncogene 2004*, Chamorro et al., EMBO J 2005*, González-Sancho et al., Oncogene 2005*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
ID2 (ID2)
(transcription, activates)
Rockman et al., J Biol Chem 2001*, Memezawa et al., Oncogene 2007*, Ye et al., Nat Neurosci 2009
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4/beta catenin complex (TCF7L2-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4/TLE2 complex (TCF7L2-TLE2)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TLE2 (TLE2)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/TLE2 complex (TCF7L2-TLE2)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
JUN (JUN)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
DVL3 (DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
JUN (JUN)
→
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
DVL3 (DVL3)
→
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
KLF4 (KLF4)
(modification, collaborate)
Evans et al., Mol Cell Biol 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4)
(modification, collaborate)
Evans et al., Mol Cell Biol 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
KLF4 (KLF4)
→
TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4)
(modification, collaborate)
Evans et al., Mol Cell Biol 2010
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/p300 complex (TCF7L2-CTNNB1-EP300)
(modification, collaborate)
Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
p300 (EP300)
(modification, collaborate)
Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4)
(modification, collaborate)
Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/p300 complex (TCF7L2-CTNNB1-EP300)
→
p300 (EP300)
(modification, collaborate)
Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
p300 (EP300)
→
TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4)
(modification, collaborate)
Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TIP49B (RUVBL2)
(modification, collaborate)
Bauer et al., EMBO J 2000, Weiske et al., J Cell Sci 2005, Rashid et al., J Biol Chem 2009
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/TIP49B complex (TCF7L2-CTNNB1-RUVBL2)
(modification, collaborate)
Bauer et al., EMBO J 2000, Weiske et al., J Cell Sci 2005, Rashid et al., J Biol Chem 2009
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TIP49B (RUVBL2)
→
TCF4/beta catenin/TIP49B complex (TCF7L2-CTNNB1-RUVBL2)
(modification, collaborate)
Bauer et al., EMBO J 2000, Weiske et al., J Cell Sci 2005, Rashid et al., J Biol Chem 2009
Evidence: reporter gene, physical interaction
-
Reactome Reaction:
TCF7L2
→
CTNNB1
(reaction)
Omer et al., Biochem Biophys Res Commun 1999, Chen et al., Genes Dev 1999, Chen et al., Gene 2000, Graham et al., Cell 2000, Poy et al., Nat Struct Biol 2001, Brantjes et al., Biol Chem 2002, Song et al., Mol Cell Biol 2004, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009, Molenaar et al., Cell 1996, Behrens et al., Nature 1996, Pinto et al., J Biol Chem 1996, van de Wetering et al., Cell 1997, Korinek et al., Mol Cell Biol 1998, Levanon et al., Proc Natl Acad Sci U S A 1998, Chen et al., Mol Cell Biol 1998
-
Reactome Reaction:
TCF7L2
→
CTNNB1
(direct_complex)
Kramps et al., Cell 2002, Thompson et al., Nat Cell Biol 2002, Belenkaya et al., Development 2002, Ishitani et al., Mol Cell Biol 2003*, Hoffmans et al., Development 2004, Hoffmans et al., Curr Biol 2005, Städeli et al., Mech Dev 2005, Sierra et al., Genes Dev 2006, Shilatifard et al., Annu Rev Biochem 2006, Sampietro et al., Mol Cell 2006, Schwab et al., BMC biology 2007, Song et al., Development 2007, Li et al., Genesis 2007, Sustmann et al., Mol Cell Biol 2008, Jessen et al., Bioessays 2008, Fiedler et al., Mol Cell 2008, Gu et al., J Cell Biol 2009, Kessler et al., Mech Dev 2009, Gu et al., Cell cycle (Georgetown, Tex.) 2012, Valenta et al., Genes Dev 2011, Valenta et al., EMBO J 2012, Willis et al., Blood 1998
-
WikiPathways Wnt Signaling Pathway and Pluripotency:
CTNNB1
→
Complex of TCF7L2-LEF1-TCF7L1-TCF7
(activation)
-
WikiPathways Arrhythmogenic Right Ventricular Cardiomyopathy:
CTNNB1
→
LEF1/TCF7/TCF7L2/TCF7L1
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
TCF7/TCF7L1/TCF7L2/LEF1
→
CTNNB1
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of JUN-CTNNB1-TCF7L2
Nateri et al., Nature 2005
-
IRef Bind_translation Interaction:
CTNNB1
—
TCF7L2
(affinity chromatography technology)
Hamada et al., Dev Cell 2004
-
IRef Bind_translation Interaction:
CTNNB1
—
TCF7L2
(coimmunoprecipitation)
Hamada et al., Dev Cell 2004
-
IRef Bind_translation Interaction:
CTNNB1
—
TCF7L2
(two hybrid)
Hoffmans et al., Development 2004
-
IRef Bind_translation Interaction:
CTNNB1
—
TCF7L2
(coimmunoprecipitation)
Nateri et al., Nature 2005
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(physical association, affinity chromatography technology)
Del Valle-Pérez et al., J Cell Sci 2011*
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(physical association, affinity chromatography technology)
Hong et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(direct interaction, pull down)
Tzeng et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(physical association, affinity chromatography technology)
Tzeng et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(physical association, affinity chromatography technology)
Kennell et al., Mol Cell Biol 2003*
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(physical association, affinity chromatography technology)
Lukas et al., Nucleic Acids Res 2009*
-
IRef Biogrid Interaction:
CTNNB1
—
TCF7L2
(physical association, affinity chromatography technology)
Idogawa et al., Cancer Res 2007
-
MIPS CORUM Bipartite complex (TFC4, CTNNB1):
Bipartite complex (TFC4, CTNNB1) complex (CTNNB1-TCF7L2)
Yook et al., Nat Cell Biol 2006*
-
IRef Corum Interaction:
TCF7L2
—
CTNNB1
(association, coimmunoprecipitation)
Yook et al., Nat Cell Biol 2006*
-
IRef Dip Interaction:
CTNNB1
—
TCF7L2
(physical association, anti tag coimmunoprecipitation)
Yang et al., Nature 2011*
-
IRef Dip Interaction:
CTNNB1
—
TCF7L2
(physical association, anti bait coimmunoprecipitation)
Rosanò et al., Proc Natl Acad Sci U S A 2009*
-
IRef Dip Interaction:
CTNNB1
—
TCF7L2
(physical association, pull down)
Notani et al., PLoS Biol 2010*
-
IRef Hprd Interaction:
CTNNB1
—
TCF7L2
(in vivo)
Poy et al., Nat Struct Biol 2001, Kennell et al., Mol Cell Biol 2003*, Edlund et al., Mol Cell Biol 2005*, Raurell et al., J Biol Chem 2006*
-
IRef Hprd Interaction:
CTNNB1
—
TCF7L2
(in vitro)
Poy et al., Nat Struct Biol 2001, Kennell et al., Mol Cell Biol 2003*, Edlund et al., Mol Cell Biol 2005*, Raurell et al., J Biol Chem 2006*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Tzeng et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Ito et al., Cancer Cell 2008*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, anti tag coimmunoprecipitation)
Zhang et al., Cancer Cell 2011*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(direct interaction, x-ray crystallography)
Graham et al., Nat Struct Biol 2001*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(direct interaction, x-ray crystallography)
Poy et al., Nat Struct Biol 2001
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Raurell et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, pull down)
Raurell et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Ress et al., FEBS Lett 2006*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(direct interaction, anti bait coimmunoprecipitation)
Tzeng et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, anti tag coimmunoprecipitation)
Tzeng et al., J Biol Chem 2006*
-
IRef Intact Interaction:
TCF7L2
—
CTNNB1
(physical association, anti tag coimmunoprecipitation)
Valenta et al., EMBO J 2006*
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti tag coimmunoprecipitation)
Zhang et al., Cancer Cell 2011*
-
IRef Intact Interaction:
Complex of 248 proteins
(association, pull down)
von Eyss et al., EMBO J 2012
-
IRef Intact Interaction:
Complex of TCF7L2-CTNNB1-TNIK-CTNNB1-TCF7L2-TNIK
(association, anti bait coimmunoprecipitation)
Mahmoudi et al., EMBO J 2009*
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti bait coimmunoprecipitation)
Idogawa et al., Cancer Res 2007
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Raurell et al., J Biol Chem 2006*
-
IRef Intact Interaction:
Complex of XRCC6-CTNNB1-TCF7L2
(association, anti tag coimmunoprecipitation)
Idogawa et al., Cancer Res 2007
-
IRef Intact Interaction:
Complex of 37 proteins
(association, anti tag coimmunoprecipitation)
Ito et al., Cancer Cell 2008*
-
IRef Intact Interaction:
Complex of CTNNB1-JUP-CTNNB1-TCF7L2-CTNNB1-JUP-TCF7L2-JUP-TCF7L2
(association, anti bait coimmunoprecipitation)
Raurell et al., J Biol Chem 2006*
-
IRef Intact Interaction:
Complex of CTNNB1-TCF7L2
(association, pull down)
Raurell et al., J Biol Chem 2006*
-
IRef Ophid Interaction:
TCF7L2
—
CTNNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Shih et al., Cancer Res 2000
(Colorectal Neoplasms) :
When expressed in colon cancer cells, Ad-CBR blocked the nuclear translocation of
beta-catenin and
inhibited beta-catenin/Tcf-4 mediated transactivation
Ogino et al., J Biol Chem 2001
:
Bipartite binding of a kinase activator
activates Cdc7 related kinase essential for S phase
Song et al., Mol Cell Biol 2003
:
We also demonstrated cross talk between the WNT and androgen receptor signaling pathways because excess androgen receptor could interfere with WNT signaling and excess
TCF-4 inhibited the interaction of
beta-catenin and androgen receptor
Yamamoto et al., EMBO J 2003
:
PIASy enhanced
beta-catenin dependent transcriptional activity of
Tcf-4 , whereas Axam inhibited it ... Furthermore,
beta-catenin and PIASy
activated Tcf-4 ( K297R ), in which Lys297 was changed to arginine, less than wild-type Tcf-4
Nath et al., Proc Natl Acad Sci U S A 2003
(Colonic Neoplasms) :
We determined
Beta-catenin dependent
TCF-4 transcriptional activity by measuring the activity of the luciferase gene placed under the control of TCF-4 regulatory sequences
Alvarado et al., Genetics 2004
:
Bipartite inhibition of Drosophila
epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1
Kanda et al., J Cell Biochem 2005
:
Association with
beta-catenin enhances the transcriptional activity of
T-cell factor-4 (TCF-4) , which up-regulates the expression of fibronectin
Chi et al., Genes Dev 2007
:
Bipartite stimulatory
action of the Hop2-Mnd1 complex on the
Rad51 recombinase
Lim et al., Cancer Res 2008
:
Moreover, HIF-1alpha disruption of
hARD1/beta-catenin repressed
TCF4 activity, resulting in c-Myc suppression and p21 ( cip1 ) induction
Feng et al., J Physiol 2009
(Atrophy) :
Based on these findings, the loss of EC proliferation with TPN may well be due to a loss of total beta-catenin, as well as a concomitant change in the differential expression of beta-catenin phosphorylation sites, and a reduction in
beta-catenin mediated
tcf-4 transcription
Huang et al., Biochem Biophys Res Commun 2009
:
Constitutive
activation of the transcription factor
TCF4 activity by mutated APC or
beta-catenin contributes to cell neoplastic transformation
Kaur et al., Neoplasia (New York, N.Y.) 2010
(Colorectal Neoplasms) :
Other studies, therefore, were performed only in SW480 cells where silibinin significantly decreased
beta-catenin dependent
T-cell factor-4 (TCF-4) transcriptional activity and protein expression of beta-catenin target genes such as c-Myc and cyclin D1
Thévenod et al., Curr Mol Med 2010
(Kidney Neoplasms...) :
Wnt signaling may contribute to Cd2+ carcinogenesis because Cd2+ disrupts the junctional E-cadherin/beta-catenin complex, resulting in excessive nuclear translocation of
beta-catenin and
activation of
Tcf4