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CTNNB1 — PYGO2

Pathways - manually collected, often from reviews:

• Reactome Reaction: PYGO2 → CTNNB1 (reaction) Kramps et al., Cell 2002, Thompson et al., Nat Cell Biol 2002, Belenkaya et al., Development 2002, Hoffmans et al., Development 2004, Hoffmans et al., Curr Biol 2005, Städeli et al., Mech Dev 2005, Sierra et al., Genes Dev 2006, Sampietro et al., Mol Cell 2006, Schwab et al., BMC biology 2007, Song et al., Development 2007, Li et al., Genesis 2007, Sustmann et al., Mol Cell Biol 2008, Jessen et al., Bioessays 2008, Fiedler et al., Mol Cell 2008, Gu et al., J Cell Biol 2009, Kessler et al., Mech Dev 2009, Gu et al., Cell cycle (Georgetown, Tex.) 2012, Valenta et al., Genes Dev 2011, Valenta et al., EMBO J 2012, Willis et al., Blood 1998
• Reactome Reaction: PYGO2 → CTNNB1 (direct_complex) Kramps et al., Cell 2002, Thompson et al., Nat Cell Biol 2002, Belenkaya et al., Development 2002, Hoffmans et al., Development 2004, Hoffmans et al., Curr Biol 2005, Städeli et al., Mech Dev 2005, Sierra et al., Genes Dev 2006, Shilatifard et al., Annu Rev Biochem 2006, Sampietro et al., Mol Cell 2006, Schwab et al., BMC biology 2007, Song et al., Development 2007, Li et al., Genesis 2007, Sustmann et al., Mol Cell Biol 2008, Jessen et al., Bioessays 2008, Fiedler et al., Mol Cell 2008, Gu et al., J Cell Biol 2009, Kessler et al., Mech Dev 2009, Gu et al., Cell cycle (Georgetown, Tex.) 2012, Valenta et al., Genes Dev 2011, Valenta et al., EMBO J 2012, Willis et al., Blood 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Mosimann et al., Cell 2006
• IRef Intact Interaction: Complex of CTNNB1-PYGO2-CDC73 (association, anti bait coimmunoprecipitation) Mosimann et al., Cell 2006

Text-mined interactions from Literome

Townsley et al., Nat Cell Biol 2004 (Neoplasms) : Lgs functions as an adaptor between Pygo and Armadillo/beta-catenin, but how Armadillo/beta-catenin is controlled by Pygo and Lgs is not known
Hoffmans et al., Curr Biol 2005 : Lgs functions as an adaptor between Arm/beta-catenin and Pygo, but different mechanisms have been proposed as to how Arm/beta-catenin is controlled by Lgs and Pygo
Kennedy et al., Dev Dyn 2010 : The Wnt/beta-catenin transcriptional activation complex requires the adapter protein Pygopus ( Pygo ) , which links the basal transcription machinery to beta-catenin, by its association with legless (Lgs)/ B-cell lymphoma-9 (Bcl9)