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BDNF — SHH

Text-mined interactions from Literome

Wu et al., Biochem Biophys Res Commun 2009 : Herein we tested whether BDNF induces SHH expression and if so, whether BDNF induction of SHH contributes to the observed neuroprotective effects ... These results indicate that BDNF induces SHH expression, which contributes to neuroprotection against 3-NP toxicity in rat cortical neurons
Wu et al., Neurobiol Dis 2010 : Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain derived neurotrophic factor against mitochondrial inhibition ... Because carbamylated erythropoietin (EPO) may induce SHH, we investigated whether BDNF dependent SHH expression and 3-NP resistance require prior induction of EPO ... BDNF mediated SHH induction and 3-NP resistance were abolished by the soluble EPO receptor ( sEPO-R ), an EPO inhibitor ... Overall, our results demonstrate that BDNF dependent SHH expression and 3-NP resistance require prior induction of EPO, thus establishing a signaling cascade of `` BDNF -- > EPO -- > SHH -- > 3-NP resistance '' in rat cortical neurons