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CDKN1A — PTGS2

Text-mined interactions from Literome

Zahner et al., J Biol Chem 2002 : These data suggest that COX-2 inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis, but involves p53, p21 ( cip-1 ), and p27 ( kip-1 )
Mäkitie et al., J Otolaryngol 2003 (Carcinoma, Squamous Cell...) : Using cell viability assay, we established the optimal in vitro inhibitory dose of celecoxib and showed that inhibition of COX-2 markedly induces the expression of p27kip1, p21 , waf1, and the F-box protein skp2
Santini et al., Apoptosis 1999 : Cyclooxygenase independent induction of p21WAF-1/cip1 , apoptosis and differentiation by L-745,337, a selective PGH synthase-2 inhibitor, and salicylate in HT-29 cells
Han et al., Lung Cancer 2006 (Carcinoma, Non-Small-Cell Lung...) : However, the anti-growth effect of the COX-2 inhibitors and their ability to induce p21 were not affected by COX-2 siRNA suggesting that their actions were COX-2 independent ... These observations unveil a mechanism for p21 gene regulation by COX-2 inhibitors in lung carcinoma cell growth and this pathway represents a potential target for therapy
Zhou et al., Cancer Lett 2009 (Necrosis...) : NO-ASA induced COX-2 expression starting 90 min after p21 ( cip-1 ) was induced