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EGFR — PTPRJ

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — PTPRJ (direct interaction, fluorescent resonance energy transfer) Tarcic et al., Curr Biol 2009*
• IRef Biogrid Interaction: EGFR — PTPRJ (physical association, affinity chromatography technology) Tarcic et al., Curr Biol 2009*
• IRef Hprd Interaction: EGFR — PTPRJ (in vivo) Jallal et al., J Biol Chem 1997*
• IRef Intact Interaction: EGFR — PTPRJ (dephosphorylation reaction, phosphatase assay) Barr et al., Cell 2009

Text-mined interactions from Literome

Berset et al., Genes Dev 2005 : During vulval development, DEP-1 inhibits EGFR signaling in the secondary cell lineage in parallel with the NOTCH mediated lateral inhibition, while EGFR signaling simultaneously down-regulates DEP-1 and NOTCH expression in the primary cell lineage
Tarcic et al., Curr Biol 2009 : DEP-1 is a tumor suppressor that dephosphorylates and thereby stabilizes EGFR by hampering its ability to associate with the CBL-GRB2 ubiquitin ligase complex