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CALM2 — EGFR
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Belcheva et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
mu-Opioid receptor mediated ERK activation involves
calmodulin dependent
epidermal growth factor receptor transactivation
Li et al., Biochem J 2002
(Carcinoma, Squamous Cell) :
Previous work from our laboratory has demonstrated that the Ca ( 2+ )
-calmodulin complex
inhibits the intrinsic tyrosine kinase activity of the
epidermal growth factor receptor (EGFR) , and that the receptor can be isolated by Ca ( 2+ ) -dependent calmodulin-affinity chromatography [ San José, Bengurija, Geller and Villalobo ( 1992 ) J. Biol. Chem. 267, 15237-15245 ]
Tebar et al., Mol Biol Cell 2002
(MAP Kinase Signaling System) :
To examine the
role of
calmodulin in the regulation of
EGFR , the effect of calmodulin antagonist, W-13, on the intracellular trafficking of EGFR and the MAPK signaling pathway was analyzed ... These data are consistent with the
regulation of
EGFR by
calmodulin at several steps of the receptor signaling and trafficking pathways
Aifa et al., Cell Signal 2002
:
Our results suggest that
EGFR-JM is
essential for epidermal growth factor (EGF) mediated
calcium-calmodulin signalling and for signal integration between other signalling pathways
Bourguignon et al., J Biol Chem 2006
(Carcinoma, Squamous Cell...) :
Overexpression of the LARG-PDZ domain also functions as a dominant negative mutant ( similar to the
PLC/Ca2+-calmodulin dependent kinase II ( CaMKII ) and
EGFR/MAPK inhibitor effects ) to block HA/CD44 mediated signaling events ( e.g. EGFR kinase activation, Ras/RhoA co-activation, Raf-ERK signaling, PLC epsilon mediated inositol 1,4,5-triphosphate production, intracellular Ca2+ mobilization, CaMKII activity, filamin phosphorylation, and filamin-actin binding ) and to abrogate tumor cell growth/migration
Deb et al., Am J Physiol Cell Physiol 2008
:
Pregnancy upregulated nonubiquitous
calmodulin kinase
induces ligand independent
EGFR degradation
Sánchez-González et al., FEBS J 2010
(Calcium Signaling) :
We also describe several mechanistic models that could account for the Ca ( 2+ )
/calmodulin mediated regulation of
epidermal growth factor receptor activity
Li et al., J Biol Chem 2012
:
Regulation of the ligand dependent
activation of the
epidermal growth factor receptor by
calmodulin