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MUC1 — TNF

Text-mined interactions from Literome

Fischer et al., Am J Respir Cell Mol Biol 1999 : Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro ... In this study, we investigated potential signaling pathways mediating TNF-alpha induced mucin secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture ... Exogenously applied TNF-alpha ( human recombinant ) stimulated mucin secretion in a concentration dependent manner, with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) ... TNF-alpha increased production of nitrite and nitrate by GPTE cells ; both mucin secretion and cGMP production were attenuated by NG-monomethyl-L-arginine ( 1 mM ), a competitive inhibitor of nitric oxide synthase (NOS), or by the GC-S inhibitor LY83583 ( 50 microM ) ; and mucin secretion in response to TNF-alpha or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) ... Collectively, the results suggest that TNF-alpha stimulates secretion of mucin by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC, and involving activation of NOS, generation of NO, production of cGMP, and activation of PKG
Choi et al., Hepatology 1999 : Exogenous tumor necrosis factor alpha (TNF-alpha) ( 1-10 ng/mL ) did cause a minor increase in mucin secretion by the DGBE cells, but the effect of LPS from E. coli on mucin secretion could not be inhibited by preincubation with a TNF-alpha antibody ( 10 microg/mL )
Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin , lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells ... The aim of this study was to examine whether TNF-alpha , IL-1beta or their combination can increase the secretion of mucin as an indicator of mucous secretion, the secretion of lysozyme as an indicator of serous secretion and the secretion of IL-6 and IL-8 as important cytokines
Grünberg et al., Tumour Biol 2000 (Breast Neoplasms) : In contrast, CAL51 cells were overall less sensitive to differentiation induction attempts ; only TNF-alpha stimulated MUC1 , isoactin and epithelial cell adhesion molecule ( Ep-CAM ) expression
Lin et al., J Infect Dis 2000 (Otitis Media with Effusion) : Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha : potential cause for mucoid otitis media
Smirnova et al., Cytokine 2000 : TNF-alpha stimulates MUC5AC mucin secretion in a dose dependent manner, with 20 ng/ml producing maximal stimulation
Smirnova et al., Eur Cytokine Netw 2001 : IL-6 and TNF-alpha stimulated MUC5AC and MUC5B mucin secretion in a time dependent manner, both in pre-confluent and post-confluent cells
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : TNFalpha in both a dose and time dependent fashion induced expression of CD11a ( LFA-1 ), CD54 ( intercellular adhesion molecule-1, ICAM-1 ), CD106 ( vascular cell adhesion molecule-1, VCAM-1 ), CD49d ( very late activating antigen-4, VLA-4 ), and/or MUC-1 on MM cell lines ; as well as CD106 ( VCAM-1 ) and CD54 ( ICAM-1 ) expression on BMSCs
Kawano et al., Ann Otol Rhinol Laryngol 2002 (Hyperplasia...) : Recent studies demonstrated that tumor necrosis factor alpha (TNF-alpha) , present in human middle ear effusion, stimulated mucin production in vitro and up-regulated mucin gene expression in vivo
Lagow et al., J Cell Biochem 2002 (Breast Neoplasms) : Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha ... We demonstrate that MUC1 expression in T47D breast cancer cells and normal human mammary epithelial cells ( HMEC ) is enhanced by tumor necrosis factor-alpha (TNF-alpha) in the presence of interferon-gamma (IFN-gamma) ... Binding of NFkappaB p65 to the MUC1 kappaB site was induced by TNF-alpha treatment, as demonstrated by electrophoretic mobility shift assay ... Collectively, these studies demonstrate synergistic stimulation of MUC1 expression by TNF-alpha and IFN-gamma that is mediated by independent actions of NFkappaB p65 and STAT1alpha upon kappaB and STAT sites, respectively, in the MUC1 promoter
Shirasaki et al., Acta Otolaryngol 2003 : TNF mediated MUC1 gene expression may contribute to the pathogenesis of human inflammatory upper airway disorders
O'Connor et al., Prostate Cancer Prostatic Dis 2005 (Prostatic Neoplasms) : Furthermore, IFN-gamma and TNF-alpha strongly induce MUC1 expression in both normal prostate epithelia and certain prostate tumor cell lines and may exacerbate pathologies associated with MUC1 positive prostate cancers
Ahn et al., Cell Physiol Biochem 2005 : The molecular mechanisms responsible for TNF-alpha mediated MUC2 intestinal mucin up-regulation in HM3 colon adenocarcinoma cells were analyzed using promoter-reporter assays of the 5'-flanking region of the MUC2 gene
Hauber et al., J Allergy Clin Immunol 2005 (Chronic Disease...) : Niflumic acid and MSI-2216 reduce TNF-alpha induced mucin expression in human airway mucosa ... Unstimulated and TNF-alpha induced mucin expression could be decreased by NFA and MSI-2216
Agrawal et al., Int Immunol 2005 : MUC1 expression on activated T cells was increased in the presence of IL-12 but was not affected by IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-13 or TNF-alpha
Baginski et al., Am J Respir Cell Mol Biol 2006 (Carcinoma, Mucoepidermoid) : We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC mucin induced by LPS or TNF-alpha in human airway epithelial NCI-H292 cells
Hamada et al., Immunology 1991 : The effects of TNF-alpha on the FC gamma IBS and mucin production could not be attributed to a decreased proliferative rate of the cells, as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected
Koga et al., Am J Physiol Lung Cell Mol Physiol 2007 : TNF-alpha induces MUC1 gene transcription in lung epithelial cells : its signaling pathway and biological implication ... The current study was conducted to elucidate the mechanism through which TNF-alpha stimulates expression of MUC1 , a membrane tethered mucin ... TNF-alpha increased MUC1 gene promoter activity in A549 cells transfected with a promoter-luciferase reporter plasmid ... Both U0126, an inhibitor of MEK1/2, and dominant negative ERK1 prevented TNF-alpha induced MUC1 promoter activation, and anti-TNFR1 antibody blocked TNF-alpha stimulated ERK1/2 activation ... MUC1 promoter activation by TNF-alpha also was blocked by mithramycin A, an inhibitor of Sp1, as well as either deletion or mutation of a putative Sp1 binding site in the MUC1 promoter located between nucleotides -99 and -90 ... TNF-alpha stimulated binding of Sp1 to the MUC1 promoter in intact cells was demonstrated by chromatin immunoprecipitation assay ... We conclude that TNF-alpha induces MUC1 gene transcription through a TNFR1 -- > MEK1/2 -- > ERK1 -- > Sp1 pathway
Brayman et al., Mol Endocrinol 2007 (Breast Neoplasms) : We and others have shown that MUC1 expression is activated by progesterone ( P ), TNF-alpha , and interferon-gamma (IFN-gamma) ... PIASy repression of basal, P-, and TNF-alpha stimulated MUC1 promoter activity was not dependent on the PIASy sumoylation domain
Blalock et al., Invest Ophthalmol Vis Sci 2008 : TNF induced the release of MUC1, MUC4 , and MUC16 from the HCLE surface ... TNF induced the release of MUC1 , MUC4, and MUC16 from the HCLE surface
Antonela Antoniu et al., Expert Opin Investig Drugs 2009 : Both LPS and TNF-alpha increased MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene
Ahmad et al., Cancer Res 2009 : Studies in nonmalignant epithelial cells show that MUC1-C interacts with NF-kappaB in the response to tumor necrosis factor-alpha stimulation
Li et al., Am J Physiol Lung Cell Mol Physiol 2010 (Respiratory Syncytial Virus Infections) : We conclude that the RSV induced increase in the TNFalpha levels upregulates MUC1 through its interaction with TNFR, which in turn suppresses further increase in TNFalpha by RSV, thus forming a negative feedback loop in the control of RSV induced inflammation
Choi et al., Am J Respir Cell Mol Biol 2011 (Pseudomonas Infections...) : These results suggest that the up-regulation of Muc1 during airway PA infection might be crucial for suppressing excessive and prolonged inflammatory responses, and is induced mainly by TNF-a , the key proinflammatory mediator
Cascio et al., J Biol Chem 2011 (Adenocarcinoma...) : ChIP and real-time PCR experiments revealed that MUC1/22TR up-regulated IL-6 and TNF-a expression by binding to their promoter regions in a NF-?B p65 dependent manner in both MUC1 transfected and human breast cancer cells that express endogenous MUC1
Kyo et al., Am J Respir Cell Mol Biol 2012 (Inflammation) : Our results showed that : ( 1 ) a lysate of NTHi increased the early release of IL-8 and later production of MUC1 protein by A549 cells in dose dependent and time dependent manners, compared with vehicle control ; ( 2 ) both effects were attenuated after transfection of the cells with a TLR2 targeting small interfering ( si ) RNA, compared with a control siRNA ; ( 3 ) the NTHi induced release of IL-8 was suppressed by an overexpression of MUC1, and was enhanced by the knockdown of MUC1 ; ( 4 ) the TNF-a released after treatment with NTHi was sufficient to up-regulate MUC1 , which was completely inhibited by pretreatment with a soluble TNF-a receptor ; and ( 5 ) primary murine tracheal surface epithelial ( MTSE ) cells from Muc1 knockout mice exhibited an increased in vitro production of NTHi stimulated keratinocyte chemoattractant compared with MTSE cells from Muc1 expressing animals
Takasuka et al., J Immunol 1995 : In contrast with J774.1 cells and thioglycolate medium elicited macrophages ( T-PEM ), P-PEM exhibited serum independent TNF-alpha production, and a polyclonal Ab to murine CD14 had no inhibitory effect on the LPS induced TNF-alpha production by P-PEM
Clark et al., Dis Markers 1994 (Ovarian Neoplasms) : Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian carcinoma cell lines ... Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian carcinoma cell lines ... TNF-alpha had little effect on MUC1 expression, but one or five days exposure to IFN-gamma significantly increased MUC1 expression ( p < 0.01 ) in all cell lines including the two cell lines that initially showed little or no expression