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CXCR4 — HGF

Text-mined interactions from Literome

Kollet et al., J Clin Invest 2003 : Unexpectedly, HGF , which is increased following liver injury, promoted protrusion formation, CXCR4 upregulation, and SDF-1 mediated directional migration by human CD34+ progenitors, and synergized with stem cell factor ... Unexpectedly, HGF , which is increased following liver injury, promoted protrusion formation, CXCR4 upregulation, and SDF-1 mediated directional migration by human CD34+ progenitors, and synergized with stem cell factor
Matteucci et al., Exp Cell Res 2005 (Anoxia...) : Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness ... Extracellular signal regulated protein kinase 1/2 ( ERK1/2 ) and phosphoinositide-3-kinase (PI3K) transduction pathways seemed to be differently implicated in the early induction of CXCR4 by hepatocyte growth factor or hypoxia in the two breast carcinoma cells examined
Maroni et al., Carcinogenesis 2007 (Breast Neoplasms...) : HGF induces CXCR4 and CXCL12 mediated tumor invasion through Ets1 and NF-kappaB
Matteucci et al., Mol Cancer Res 2007 (Breast Neoplasms...) : c-Src/histone deacetylase 3 interaction is crucial for hepatocyte growth factor dependent decrease of CXCR4 expression in highly invasive breast tumor cells ... Thus, the CXCR4 induction by HGF in MCF-7 cells required NF-kappaB and Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells, HDAC3 activation via c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB
Ridolfi et al., Br J Cancer 2008 (Breast Neoplasms...) : c-Src wild-type expression vector (Srcwt) increased active c-Src and mimicked the HGF dependent inhibition of CXCR4 transactivation
Tu et al., Onkologie 2009 (Glioma...) : In this study, we investigated the ability of HGF to promote the proliferation and invasion of U251n cells ; we also tested the effects of HGF on stromal cell derived factor 1 (SDF1) and CXCR4 mRNA expression
Esencay et al., J Neurooncol 2010 (Glioma) : HGF upregulates CXCR4 expression in gliomas via NF-kappaB : implications for glioma cell migration ... Knock-down of NF-kappaB expression inhibited the induction of CXCR4 expression in response to HGF , but not to hypoxia ... However, knock-down of NF-kappaB expression inhibited the induction of CXCR4 expression in response to hypoxia in the presence of HGF ... Therefore, HGF upregulates CXCR4 expression via NF-kappaB and leads to enhanced migration
Tesio et al., Blood 2011 : Interestingly, stromal cell derived factor 1/CXC chemokine receptor-4 signaling induced hepatocyte growth factor production and c-Met activation
Huang et al., PloS one 2012 (Breast Neoplasms...) : HGF induced PKC? activation increases functional CXCR4 expression in human breast cancer cells ... In this study, we found that HGF induced functional CXCR4 receptor expression in breast cancer cells ... Interference with the activation of Rac1, a downstream target of HGF, prevented the HGF induced increase in PKC? activity and CXCR4 levels ... Our findings thus provided evidence that the process of HGF induced functional CXCR4 expression may involve PI 3-kinase and atypical PKC?