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EGF — PTPN11
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of PTPN11-STAT1
→
EGF
(increases)
Wu et al., J Biol Chem 2002
Evidence: SHP-2 and Stat1 nuclear localization and their association in response to either epidermal growth factor or interferon-gamma (IFNgamma) were confirmed by immunofluorescent staining and affinity precipitation assays.
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NCI Pathway Database SHP2 signaling:
EGFR/EGFR/EGF/EGF/GNAI1/GNAI3/GAB1 complex (EGFR-EGF-GNAI1-GNAI3-GAB1)
→
SHP2 (PTPN11)
(translocation, activates)
Yart et al., J Biol Chem 2001
Evidence: physical interaction
-
NCI Pathway Database SHP2 signaling:
SHP2 (PTPN11)
→
EGFR/EGFR/EGF/EGF/GRB2/GAB1 complex (EGFR-EGF-GRB2-GAB1)
(modification, activates)
Zhang et al., Mol Cell Biol 2002*, Montagner et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction, other species
-
Reactome Reaction:
EGF
→
PTPN11
(reaction)
Gual et al., Oncogene 2000, Cunnick et al., J Biol Chem 2001*, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*
-
Reactome Reaction:
EGF
→
PTPN11
(indirect_complex)
Gual et al., Oncogene 2000, Cunnick et al., J Biol Chem 2001*, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*
Text-mined interactions from Literome
Hui et al., Prostaglandins Leukot Essent Fatty Acids 1999
:
The addition of 13 ( S ) -HpODE stimulated a concentration dependent increase in
EGF dependent phosphorylation of
SHP-2 and its association with EGFR
Fukunaga et al., J Biol Chem 2000
:
Overexpression of a catalytically inactive mutant ( SHP-2C/S ) of the protein-tyrosine phosphatase SHP-2 in Rat-1 fibroblasts that also express human insulin receptors has now revealed that activation of JNKs by insulin and
epidermal growth factor , but not that by anisomycin or sorbitol,
requires SHP-2
Cunnick et al., J Biol Chem 2000
:
These results establish a role for Gab1 in the LPA induced MAP kinase pathway and clearly demonstrate that
Gab1-SHP2 interaction is
essential for ERK2 activation by LPA and
EGF
Wu et al., Oncogene 2000
(Brain Neoplasms...) :
SIRPalpha1 overexpression also reduced the
EGF induced association between
SHP2 and the p85 regulatory subunit of PI3-K
Cunnick et al., J Biol Chem 2001
:
The
SHP2 PTPase activity is
required for activation of the extracellular signal regulated kinase ( ERK ) subfamily of mitogen activated protein ( MAP ) kinase by
EGF ... We found that both Tyr-627 and Tyr-659 of Gab1 were required for
SHP2 binding to Gab1 and for ERK2
activation by
EGF
Kameda et al., Cell Growth Differ 2001
:
On the other hand, Gab1 was not detected in 10W2T cells, and the
EGF dependent association of
SHP-2 with EGFR was also absent ... Exogenous Gab1 expression in transfected 10W2T cells restored the
EGF dependent association of
SHP-2 with EGFR, although it only showed a marginal effect on EGF dependent mitogenic activity
Kameda et al., Mol Cell Biol 2001
(Disease Progression...) :
Gab1 ( Delta1-103 ) retains the ability to be phosphorylated in an
EGF dependent manner and to associate with the EGF receptor and
SHP-2 upon EGF stimulation
Fragale et al., Hum Mutat 2004
(MAP Kinase Signaling System...) :
Coexpression of Grb2 associated binder-1-FF, which lacks SHP2 binding motifs, blocked the
epidermal growth factor mediated increase in
SHP2 's phosphatase activity and resulted in a dramatic reduction of extracellular signal regulated kinase 2 activation
Kolli et al., J Biol Chem 2004
:
In
response to
epidermal growth factor (EGF) ,
SHP-2 associates via its SH2 domains with tyrosyl phosphorylated MVP
Yoo et al., Biochem Biophys Res Commun 2006
:
Further experiments demonstrate that
EGF does not
activate binding of
SHP2 with HSP70 rather the binding appears to be constitutive
Guo et al., J Biol Chem 2007
(Breast Neoplasms...) :
Our results demonstrate that decreased GnT-V activity due to siRNA expression in human breast carcinoma cells resulted in an inhibition of
EGF stimulated
SHP-2 activation and, consequently, caused attenuation of the dephosphorylation of FAK induced by EGF
Tsai et al., J Cell Biol 2010
:
Using the kappa-opioid receptor ( OR [ KOR ] ) as a model, we demonstrate that
EGF activates nuclear
SHP-2 ( Src homology region 2-containing tyrosine phosphatase ), which dephosphorylates Grb7 in the nucleus
Chen et al., Biochem Pharmacol 2010
:
Incubation of cells with SPI-112Me inhibited
epidermal growth factor (EGF) stimulated
Shp2 PTP activity and Shp2 mediated paxillin dephosphorylation, Erk1/2 activation, and cell migration
Ferrari et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
In addition, we demonstrate that the PTP1B mediated dephosphorylation of Gab1 negatively affects its
EGF induced association with the phosphatase
SHP2
Díaz et al., Cell Signal 2012
:
In transgenic mice, neither PTEN nor PP2A were hyperactivated ; however,
EGF induced the rapid and transient association of
SHP-2 to Gab1, which mediates association to EGFR and activation of PI3K
Yamauchi et al., J Biol Chem 1995
(Carcinoma, Hepatocellular...) :
Further, activation of the
EGF receptor did not
result in any significant tyrosine phosphorylation of
SHPTP2 and/or the association of the 115-kDa protein with Grb2
Zhao et al., J Biol Chem 1995
:
The data suggest that the phosphatase activity of
PTP2C is partly
required for MAP kinase activation by
EGF and that PTP2C may function by dephosphorylating the 43-kDa membrane protein
Peraldi et al., Proc Natl Acad Sci U S A 1994
:
These data suggest that the
EGF induced regulation of
PTP2C activity is mediated by p44mapk
Wong et al., J Biol Chem 1996
:
This is the first demonstration of a growth factor- or cytokine induced coupling of a protein through an SH3 domain and suggests that GRB2 functions to target
PTP1D , in addition to Sos, to the plasma membrane in
response to
EGF
Thien et al., Oncogene 1997
(Lymphoma, B-Cell) :
Furthermore the expression of 70Z-Cbl greatly enhances
EGF induced tyrosine phosphorylation of the protein tyrosine phosphatase
SHP-2