Gene interactions and pathways from curated databases and text-mining

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EGF — PTPN11

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hui et al., Prostaglandins Leukot Essent Fatty Acids 1999 : The addition of 13 ( S ) -HpODE stimulated a concentration dependent increase in EGF dependent phosphorylation of SHP-2 and its association with EGFR
Fukunaga et al., J Biol Chem 2000 : Overexpression of a catalytically inactive mutant ( SHP-2C/S ) of the protein-tyrosine phosphatase SHP-2 in Rat-1 fibroblasts that also express human insulin receptors has now revealed that activation of JNKs by insulin and epidermal growth factor , but not that by anisomycin or sorbitol, requires SHP-2
Cunnick et al., J Biol Chem 2000 : These results establish a role for Gab1 in the LPA induced MAP kinase pathway and clearly demonstrate that Gab1-SHP2 interaction is essential for ERK2 activation by LPA and EGF
Wu et al., Oncogene 2000 (Brain Neoplasms...) : SIRPalpha1 overexpression also reduced the EGF induced association between SHP2 and the p85 regulatory subunit of PI3-K
Cunnick et al., J Biol Chem 2001 : The SHP2 PTPase activity is required for activation of the extracellular signal regulated kinase ( ERK ) subfamily of mitogen activated protein ( MAP ) kinase by EGF ... We found that both Tyr-627 and Tyr-659 of Gab1 were required for SHP2 binding to Gab1 and for ERK2 activation by EGF
Kameda et al., Cell Growth Differ 2001 : On the other hand, Gab1 was not detected in 10W2T cells, and the EGF dependent association of SHP-2 with EGFR was also absent ... Exogenous Gab1 expression in transfected 10W2T cells restored the EGF dependent association of SHP-2 with EGFR, although it only showed a marginal effect on EGF dependent mitogenic activity
Kameda et al., Mol Cell Biol 2001 (Disease Progression...) : Gab1 ( Delta1-103 ) retains the ability to be phosphorylated in an EGF dependent manner and to associate with the EGF receptor and SHP-2 upon EGF stimulation
Fragale et al., Hum Mutat 2004 (MAP Kinase Signaling System...) : Coexpression of Grb2 associated binder-1-FF, which lacks SHP2 binding motifs, blocked the epidermal growth factor mediated increase in SHP2 's phosphatase activity and resulted in a dramatic reduction of extracellular signal regulated kinase 2 activation
Kolli et al., J Biol Chem 2004 : In response to epidermal growth factor (EGF) , SHP-2 associates via its SH2 domains with tyrosyl phosphorylated MVP
Yoo et al., Biochem Biophys Res Commun 2006 : Further experiments demonstrate that EGF does not activate binding of SHP2 with HSP70 rather the binding appears to be constitutive
Guo et al., J Biol Chem 2007 (Breast Neoplasms...) : Our results demonstrate that decreased GnT-V activity due to siRNA expression in human breast carcinoma cells resulted in an inhibition of EGF stimulated SHP-2 activation and, consequently, caused attenuation of the dephosphorylation of FAK induced by EGF
Tsai et al., J Cell Biol 2010 : Using the kappa-opioid receptor ( OR [ KOR ] ) as a model, we demonstrate that EGF activates nuclear SHP-2 ( Src homology region 2-containing tyrosine phosphatase ), which dephosphorylates Grb7 in the nucleus
Chen et al., Biochem Pharmacol 2010 : Incubation of cells with SPI-112Me inhibited epidermal growth factor (EGF) stimulated Shp2 PTP activity and Shp2 mediated paxillin dephosphorylation, Erk1/2 activation, and cell migration
Ferrari et al., J Biol Chem 2011 (MAP Kinase Signaling System) : In addition, we demonstrate that the PTP1B mediated dephosphorylation of Gab1 negatively affects its EGF induced association with the phosphatase SHP2
Díaz et al., Cell Signal 2012 : In transgenic mice, neither PTEN nor PP2A were hyperactivated ; however, EGF induced the rapid and transient association of SHP-2 to Gab1, which mediates association to EGFR and activation of PI3K
Yamauchi et al., J Biol Chem 1995 (Carcinoma, Hepatocellular...) : Further, activation of the EGF receptor did not result in any significant tyrosine phosphorylation of SHPTP2 and/or the association of the 115-kDa protein with Grb2
Zhao et al., J Biol Chem 1995 : The data suggest that the phosphatase activity of PTP2C is partly required for MAP kinase activation by EGF and that PTP2C may function by dephosphorylating the 43-kDa membrane protein
Peraldi et al., Proc Natl Acad Sci U S A 1994 : These data suggest that the EGF induced regulation of PTP2C activity is mediated by p44mapk
Wong et al., J Biol Chem 1996 : This is the first demonstration of a growth factor- or cytokine induced coupling of a protein through an SH3 domain and suggests that GRB2 functions to target PTP1D , in addition to Sos, to the plasma membrane in response to EGF
Thien et al., Oncogene 1997 (Lymphoma, B-Cell) : Furthermore the expression of 70Z-Cbl greatly enhances EGF induced tyrosine phosphorylation of the protein tyrosine phosphatase SHP-2