Gene interactions and pathways from curated databases and text-mining

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IL12B — IL12RB2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Rogge et al., J Immunol 1999 (Asthma...) : In the presence of IL-12 , cell surface expression of the IL-12R beta 2 subunit was readily detected on T cells after 24 h, reached the maximum at day 5, and declined thereafter
Wu et al., Eur J Immunol 2000 : Using an antibody specific for the human IL-12Rbeta2 subunit, the effect of IFN-gamma, IFN-alpha, IL-12 and IL-2 on the regulation of IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed
Wu et al., J Immunol 2000 : To investigate the role of IL-12R beta 2 in IL-12 signaling, we have generated IL-12R beta 2-deficient ( IL-12R beta 2 ( -/- ) ) mice by targeted mutation in embryonic stem ( ES ) cells
Parrello et al., J Immunol 2000 (Colitis...) : Finally, we showed that stimulation of lamina propria mononuclear cells with IL-12 enhanced IL-12Rbeta2 , suggesting that IL-12 regulates IL-12Rbeta2 expression in human gastrointestinal mucosa
Elloso et al., Eur J Immunol 2001 : Analysis of IL-12R expression revealed that IL-12 induced similar levels of IL-12R beta2 mRNA expression in WT and CD28 ( -/- ) cells
Makrigiannis et al., J Leukoc Biol 2001 : Moreover, IL-12Rbeta2 expression by T cells activated in the presence of anti-CD86 mAb is enhanced by IL-12
Smits et al., Eur J Immunol 2001 (Hypersensitivity) : These reversed cells are further characterized by a marked IL-12Rbeta2 chain expression and fully restored IL-12-inducible STAT4 activation
Padigel et al., J Immunol 2001 (Leishmaniasis, Cutaneous) : At wk 9 of infection, we detected similar levels of IL-4, IFN-gamma, IL-12p40 , and IL-12Rbeta2 mRNA in draining lymph nodes of healing C57BL/6, CD28 ( -/- ), and CD40L ( -/- ) CD28 ( -/- ) mice, whereas CD40L ( -/- ) mice had increased mRNA levels for IL-4 but reduced levels for IFN-gamma, IL-12p40, and IL-12Rbeta2
Belladonna et al., J Immunol 2002 : In addition, the in vitro effects of IL-23-Ig did not appear to require IL-12Rbeta2 or to be mediated by the production of IL-12
Smeltz et al., J Immunol 2002 : In the absence of IL-4, IL-12 dependent up-regulation of IL-18Ralpha/IL-12Rbeta2 was independent of IFN-gamma
Okazawa et al., Am J Gastroenterol 2002 (Crohn Disease...) : The functional activity of IL- 12 and IL-18 was assessed by the effect of recombinant IL-12 and recombinant IL-18 on interferon-gamma production, the proliferative response, and the induction of IL-2R, IL-12R , and IL-18R of LPLs
Wu et al., J Neuroimmunol 2003 (Encephalomyelitis, Autoimmune, Experimental...) : The IL-12R beta 2 expression on Th1 cells from draining LNC was increased in the presence of IL-12 and IFN-gamma
Letimier et al., EMBO J 2007 : However, high-level IL-12Rbeta2 expression required TCR triggering in the presence of IL-12
de Arquer et al., J Leukoc Biol 2007 (HIV Infections) : Moreover, exogenous IL-12 and IL-18 induced the up-regulation of IL-12Rbeta2 to twice higher in CD4 T cells from HIV-1 positive individuals compared with controls
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R , IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Naume et al., Cytokine 1993 : IL-12 enhanced the IL-12 receptor (R) expression and IL-4R expression in the CD56+ NK cells ... The increased IL-4R expression induced by IL-12 and the increased IL-12R expression induced by IL-4 may explain the synergistic proliferative activity detected in response to IL-12 and IL-4
Presky et al., Ann N Y Acad Sci 1996 : Mouse IL-12 p40 subunit homodimer ( mo ( p40 ) 2 ) blocked 125I-huIL-12 binding to human IL-12R beta 1, but did not inhibit binding to human IL-12R beta 2
Jones et al., Infect Immun 1998 (Disease Models, Animal...) : Neutralizing IL-4 and the administration of exogenous IL-12 upregulate IL-12R expression in BALB/c mice, while the neutralization of IL-12 in C3H mice blocks increased IL-12 receptor expression
Fujimiya et al., Clin Cancer Res 1997 (Brain Neoplasms...) : Thus, the increased expression of the IL-2Rbeta is critical for the synergistic activation of gammadelta T cells by IL-12 plus IL-2 ; it is also probable that at least the low-affinity IL-12R contributes to the activation of gammadelta T cells mediated by either IL-12 alone or IL-12 plus IL-2
Ding et al., J Immunol 1998 : The provision of excess costimulation can overcome some of the defects in T cell activation by weak agonists, but is insufficient to induce a sufficient level of CD40L expression needed for engagement of CD40 on APC with subsequent IL-12 production and induction of IL-12Rbeta2 chain expression
Hyodo et al., J Immunol 1999 : These data suggested that NK cells develop and express IL-12R and IL-18R in the absence of IL-12 or IL-18, and that both IL-18 and IL-12 directly and independently augment perforin mediated cytotoxic activity of NK cells