Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Cottet et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1) : SOCS-1 protein prevents Janus Kinase/STAT dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma
Carvalheira et al., Biol Chem 2003 : Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase mediated signaling in rat liver
Gottardello Zecchin et al., Vascul Pharmacol 2005 (Insulin Resistance...) : Moreover, it is shown that, in obese animals, JAK2/STAT and MAP kinase pathways are hyper activated in response to insulin , which occurs in association with a reduced activation of PI 3-kinase/Akt pathway in aorta
Kim et al., Mol Cell Endocrinol 2007 : The findings on beta-cell protective effects of genistein were essentially the same as for the RIN cell data, namely genistein prevented cytokine induced NO production, iNOS expression, ERK-1/2 activation, JAK/STAT activation , and impairment of glucose stimulated insulin secretion
Jeong et al., Toxicol In Vitro 2011 : Sauchinone prevented cytokine induced NO production, iNOS expression, JAK/STAT activation , and NF-?B activation and inhibition of glucose stimulated insulin secretion ( GSIS )