Gene interactions and pathways from curated databases and text-mining

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FOS — TGFB1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro ... In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Imai et al., Infect Immun 2000 : Since TGF-beta1 pretreatment inhibited LPS stimulated expression of c-fos and c-jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 (AP-1), a heterodimer of c-Fos and c-Jun, in the cells, TGF-beta1 inhibition of CD14 expression may be a consequence of downregulation of AP-1
Finlay et al., J Biol Chem 2000 : Dependence of ERK/AP-1 activation on bFGF induction was demonstrated by inhibition of TGF-beta1 induced ERK/AP-1 activation when conditioned medium from TGF-beta1 treated cells was incubated with bFGF neutralizing antibody
Junn et al., J Immunol 2000 : NAC also reduced TGF-beta1 induced AP-1 binding activity, which is involved in IL-6 gene expression
Palcy et al., J Bone Miner Res 2000 : Protein kinase C ( PKC ) - and protein tyrosine kinase ( PTK ) -dependent pathways have been implicated in both TGF-beta1 signaling and AP-1 gene regulation
Chipuk et al., J Biol Chem 2002 (Adenocarcinoma...) : We show that androgens ( dihydrotestosterone and R1881 ) down-regulate TGF-beta1 induced expression of TGF-beta1, c-Fos , and Egr-1 in the human prostate adenocarcinoma cell line, LNCaP
Zhou et al., Zhonghua Yi Xue Za Zhi 2002 : To clarify whether the activating protein-1 (AP-1) is involved in the transcriptional regulation of expression of oxidized low density lipoprotein ( Ox-LDL ) induced transforming growth factor (TGF)-beta(1) gene and further to investigate the possible signal transduction pathway in the cultured mesangial cells ( MsCs )
Arsura et al., Oncogene 2003 (Carcinoma, Hepatocellular...) : Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Weigert et al., Biochem Biophys Res Commun 2003 : c-Fos-driven transcriptional activation of transforming growth factor beta-1 : inhibition of high glucose induced promoter activity by thiazolidinediones
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003 : The EMSAs demonstrated that both IL-1beta and TGF-beta1 induced AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
Park et al., Oncogene 2003 (Prostatic Neoplasms) : TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6 ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the TGF-beta1 induction of IL-6 in an AP-1 dependent manner
Baroni et al., J Cutan Pathol 2004 (Psoriasis) : We found that M. furfur up-regulates transforming growth factor-beta1 ( TGF-beta1 ), integrin chain, and HSP70 expression in human keratinocytes via AP-1 dependent mechanism
Guo et al., Diabetes 2004 : PPAR-gamma overexpression inhibited TGF-beta 1-induced fibronectin expression as well as the activation of AP-1 ... 15-Deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ), a natural PPAR-gamma ligand, also inhibited TGF-beta1 induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1 ... In conclusion, pioglitazone inhibits TGF-beta 1-induced fibronectin expression by inhibiting AP-1 activation dependent on PPAR-gamma, while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells
Stanley et al., Biochem Biophys Res Commun 2005 (Neovascularization, Pathologic...) : These effects are caused by the inhibition of constitutively active AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and TGF-beta1 from PC-3 cells
Lee et al., J Immunol 2006 : Our results suggest that IL-1beta stimulated transcription of TGF-beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites
Chiarpotto et al., Biofactors 2005 (Fibrosis) : Moreover, we demonstrate that HNE can indeed contribute to the onset of fibrosis by stimulating AP-1 binding to DNA and consequently inducing TGFbeta1 expression, since thiol-group reagents, such as N-ethylmaleimide and 4- ( chloro-mercuri ) -benzenesulfonic acid, that down-modulate HNE entrance and localisation inside the cell, prevent both phenomena
Harding et al., Kidney Int 2006 : TGFbeta1 increased transcription by approximately 50 % and activated both AP-1 and NF-kappaB
Hu et al., Lung 2006 : In addition, dominant negative mutant c-Jun ( TAM67 ) downregulated TGF-beta1 induced AP-1 transactivation and alpha-SMA expression ... In additional, PD98059 but not SB203580 inhibited the AP-1 DNA binding activity induced by TGF-beta1
Liu et al., Mol Carcinog 2006 (Carcinoma...) : c-Fos is required for TGFbeta1 production and the associated paracrine migratory effects of human colon carcinoma cells ... Our results indicate for the first time that c-Fos binding at the TGFbeta1 promoter proximal AP-1 site in HCCCs is required for TGFbeta1 production by the tumor cells
Zhang et al., Am J Pathol 2006 : Furthermore, Smad3 blockade specifically inhibited activation of the transcription factor AP-1 by TGF-beta1 , whereas PD98059 prevented TGF-beta1 dependent nuclear factor-kappaB activation
Dhandapani et al., J Neurosci Res 2007 (Brain Neoplasms...) : Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Lee et al., Oncogene 2009 : A promoter deletion analysis suggested that activating protein 1 (AP-1) plays a role in TGFbeta1 gene transactivation, which was corroborated by the observation that a deficiency of the G-proteins decreased the AP-1 activity, whereas their activation enhanced it
Han et al., J Korean Med Sci 2009 (MAP Kinase Signaling System) : We examined the role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) in the aldosterone induced TGF-beta(1) expression in rat mesangial cells
Wu et al., J Am Soc Nephrol 2009 (Diabetes Mellitus, Experimental...) : Finally, pharmacologic and dominant negative inhibition of EGFR blocked glucose induced activation of PKC-beta1, phosphorylation of AktS473, activation of AP-1 , and upregulation of TGF-beta1
Shi et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009 : To investigate the expression of CTGF, CTGF mRNA, NF-kappaB and AP-1 induced by TGF-beta1 in human lung fibroblast ( HLF-02 ), and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 ... The effects of TGF-beta1 , curcumin, PDTC and rosiglitazone on the expression of CTGF, NF-kappaB and AP-1 were evaluated with Western blot
Markovics et al., J Biol Chem 2010 (Inflammation) : Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1 , and the p38 pathway
Kerr et al., Cell 1990 : These results suggest that TGF-beta 1 inhibition of gene expression is mediated by the binding of a Fos containing protein complex to the TIE promoter sequences
Uría et al., J Biol Chem 1998 : Finally, by using electrophoretic mobility shift assays and antibody supershift analysis, we propose that c-Fos , c-Jun, and JunD may play major roles in the collagenase-3 activation by TGF-beta1 in human fibroblasts
Han et al., J Pharmacol Exp Ther 1998 : Under identical condition, we examined the effect of TGF-beta1 on the activity of nuclear factor AT ( NF-AT ), nuclear factor kappaB (NF-kappaB), activator protein-1 (AP-1) and octamer, all of which contribute to the regulation of IL-2 gene expression ... Electrophoretic mobility shift assays showed that TGF-beta1 markedly increased NF-AT, NF-kappaB and AP-1 binding to their respective cognate DNA binding sites, whereas octamer binding remained constant, as compared with untreated cells