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FOS — TGFB1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
FOS
→
TGFB1
(increases, TGFB1 Activity)
Evidence: he DNA binding activities of c-Fos, FosB/Delta FosB, Fra-1, Fra-2, and JunB were up-regulated whereas JunD activity was decreased.
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NCI Pathway Database AP-1 transcription factor network:
JUN/FOS complex (FOS-JUN)
→
TGFB1 (TGFB1)
(transcription, activates)
Sullivan et al., J Cell Mol Med 2009*, Kim et al., Mol Cell Biol 1990*
Evidence: reporter gene, physical interaction
Text-mined interactions from Literome
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ),
transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors
AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro ... In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ),
transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors
AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Imai et al., Infect Immun 2000
:
Since TGF-beta1 pretreatment inhibited LPS stimulated expression of c-fos and c-jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 (AP-1), a heterodimer of c-Fos and c-Jun, in the cells,
TGF-beta1 inhibition of CD14 expression may be a
consequence of downregulation of
AP-1
Finlay et al., J Biol Chem 2000
:
Dependence of ERK/AP-1 activation on bFGF induction was demonstrated by inhibition of
TGF-beta1 induced
ERK/AP-1 activation when conditioned medium from TGF-beta1 treated cells was incubated with bFGF neutralizing antibody
Junn et al., J Immunol 2000
:
NAC also reduced
TGF-beta1 induced
AP-1 binding activity, which is involved in IL-6 gene expression
Palcy et al., J Bone Miner Res 2000
:
Protein kinase C ( PKC ) - and protein tyrosine kinase ( PTK ) -dependent pathways have been implicated in both
TGF-beta1 signaling and
AP-1 gene
regulation
Chipuk et al., J Biol Chem 2002
(Adenocarcinoma...) :
We show that androgens ( dihydrotestosterone and R1881 ) down-regulate
TGF-beta1 induced expression of TGF-beta1,
c-Fos , and Egr-1 in the human prostate adenocarcinoma cell line, LNCaP
Zhou et al., Zhonghua Yi Xue Za Zhi 2002
:
To clarify whether the
activating protein-1 (AP-1) is
involved in the transcriptional regulation of expression of oxidized low density lipoprotein ( Ox-LDL ) induced
transforming growth factor (TGF)-beta(1) gene and further to investigate the possible signal transduction pathway in the cultured mesangial cells ( MsCs )
Arsura et al., Oncogene 2003
(Carcinoma, Hepatocellular...) :
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by
TGF-beta1 inhibits
AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Weigert et al., Biochem Biophys Res Commun 2003
:
c-Fos-driven transcriptional
activation of
transforming growth factor beta-1 : inhibition of high glucose induced promoter activity by thiazolidinediones
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003
:
The EMSAs demonstrated that both IL-1beta and
TGF-beta1 induced
AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
Park et al., Oncogene 2003
(Prostatic Neoplasms) :
TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the
JNK-c-Jun-AP-1 signaling
plays a pivotal role in
TGF-beta1 stimulation of IL-6 ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the
TGF-beta1 induction of IL-6 in an
AP-1 dependent manner
Baroni et al., J Cutan Pathol 2004
(Psoriasis) :
We found that M. furfur up-regulates
transforming growth factor-beta1 ( TGF-beta1 ), integrin chain, and HSP70 expression in human keratinocytes via
AP-1 dependent mechanism
Guo et al., Diabetes 2004
:
PPAR-gamma overexpression inhibited
TGF-beta 1-induced fibronectin expression as well as the
activation of
AP-1 ... 15-Deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ), a natural PPAR-gamma ligand, also inhibited TGF-beta1 induced fibronectin expression by suppressing
AP-1 activation by
TGF-beta 1 ... In conclusion, pioglitazone
inhibits TGF-beta 1-induced fibronectin expression by inhibiting
AP-1 activation dependent on PPAR-gamma, while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells
Stanley et al., Biochem Biophys Res Commun 2005
(Neovascularization, Pathologic...) :
These effects are
caused by the inhibition of constitutively active
AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and
TGF-beta1 from PC-3 cells
Lee et al., J Immunol 2006
:
Our results suggest that IL-1beta stimulated transcription of
TGF-beta1 is temporally
regulated by NF-kappaB and
AP-1 and involves histone hyperacetylation at distinct promoter sites
Chiarpotto et al., Biofactors 2005
(Fibrosis) :
Moreover, we demonstrate that HNE can indeed contribute to the onset of fibrosis by stimulating
AP-1 binding to DNA and consequently
inducing TGFbeta1 expression, since thiol-group reagents, such as N-ethylmaleimide and 4- ( chloro-mercuri ) -benzenesulfonic acid, that down-modulate HNE entrance and localisation inside the cell, prevent both phenomena
Harding et al., Kidney Int 2006
:
TGFbeta1 increased transcription by approximately 50 % and
activated both
AP-1 and NF-kappaB
Hu et al., Lung 2006
:
In addition, dominant negative mutant c-Jun ( TAM67 ) downregulated
TGF-beta1 induced
AP-1 transactivation and alpha-SMA expression ... In additional, PD98059 but not SB203580 inhibited the
AP-1 DNA binding activity
induced by
TGF-beta1
Liu et al., Mol Carcinog 2006
(Carcinoma...) :
c-Fos is
required for
TGFbeta1 production and the associated paracrine migratory effects of human colon carcinoma cells ... Our results indicate for the first time that
c-Fos binding at the TGFbeta1 promoter proximal AP-1 site in HCCCs is
required for
TGFbeta1 production by the tumor cells
Zhang et al., Am J Pathol 2006
:
Furthermore, Smad3 blockade specifically inhibited
activation of the transcription factor
AP-1 by
TGF-beta1 , whereas PD98059 prevented TGF-beta1 dependent nuclear factor-kappaB activation
Dhandapani et al., J Neurosci Res 2007
(Brain Neoplasms...) :
Induction of
transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is
mediated by MEK/ERK signaling and
AP-1 activation
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008
:
To study the
role of
activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and
transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Seppänen et al., Acta Obstet Gynecol Scand 2008
(Carcinoma, Endometrioid...) :
We were able to show that IFN-gamma,
TGF-beta(1) and TNF-alpha all
increased the binding activity of transcription factor
AP-1 ( AP-1 )
Lee et al., Oncogene 2009
:
A promoter deletion analysis suggested that
activating protein 1 (AP-1) plays a role in
TGFbeta1 gene transactivation, which was corroborated by the observation that a deficiency of the G-proteins decreased the AP-1 activity, whereas their activation enhanced it
Han et al., J Korean Med Sci 2009
(MAP Kinase Signaling System) :
We examined the
role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and
activator protein-1 (AP-1) in the aldosterone induced
TGF-beta(1) expression in rat mesangial cells
Wu et al., J Am Soc Nephrol 2009
(Diabetes Mellitus, Experimental...) :
Finally, pharmacologic and dominant negative inhibition of EGFR blocked glucose induced activation of PKC-beta1, phosphorylation of AktS473,
activation of
AP-1 , and upregulation of
TGF-beta1
Shi et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009
:
To investigate the expression of CTGF, CTGF mRNA, NF-kappaB and
AP-1 induced by
TGF-beta1 in human lung fibroblast ( HLF-02 ), and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 ... The
effects of
TGF-beta1 , curcumin, PDTC and rosiglitazone on the expression of CTGF, NF-kappaB and
AP-1 were evaluated with Western blot
Markovics et al., J Biol Chem 2010
(Inflammation) :
Transcription of the
transforming growth factor beta activating integrin beta8 subunit is
regulated by SP3,
AP-1 , and the p38 pathway
Kerr et al., Cell 1990
:
These results suggest that
TGF-beta 1 inhibition of gene expression is
mediated by the binding of a
Fos containing protein complex to the TIE promoter sequences
Uría et al., J Biol Chem 1998
:
Finally, by using electrophoretic mobility shift assays and antibody supershift analysis, we propose that
c-Fos , c-Jun, and JunD may
play major roles in the collagenase-3 activation by
TGF-beta1 in human fibroblasts
Han et al., J Pharmacol Exp Ther 1998
:
Under identical condition, we examined the
effect of
TGF-beta1 on the activity of nuclear factor AT ( NF-AT ), nuclear factor kappaB (NF-kappaB),
activator protein-1 (AP-1) and octamer, all of which contribute to the regulation of IL-2 gene expression ... Electrophoretic mobility shift assays showed that
TGF-beta1 markedly
increased NF-AT, NF-kappaB and
AP-1 binding to their respective cognate DNA binding sites, whereas octamer binding remained constant, as compared with untreated cells