◀ Back to MAPK1
CAMK4 — MAPK1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK1
→
CAMK4
(increases, CAMK4 Activity, MAPK1 Activity)
Evidence: although all of these effects are far less substantial than those of the accepted activators AMP kinase kinase, phosphoinositide-dependent kinase 1, and CaMKK, respectively (24-26). Finally, Ras-independent activation of the mitogen-activated protein kinases ERK2, p38, and JNK1 was observed in cells transfected with constitutively active CaMKIV and further enhanced by cotransfection with CaMKK (27).
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KEGG Cholinergic synapse:
CAMK2A/CAMK2B/CAMK2D/CAMK2G/CAMK4
→
MAPK1/MAPK3
(protein-protein, activation)
Text-mined interactions from Literome
Rosengart et al., Shock 2000
:
Inhibition of
CaMK IV , both after adherence and in non-adherent monocytes, significantly
inhibited LPS induced
ERK 1/2 activation and abrogated TNFalpha production by up to 75 % ... These data suggest that the function of
CaMK II in TNFalpha production by adherent monocytes occurs during adhesion, is
mediated in part by activation of
ERK 1/2 , and appears to `` prime '' the monocyte for enhanced cytokine production
Cuschieri et al., Shock 2003
(MAP Kinase Signaling System...) :
CaMK blockade inhibited LPS
induced ERK 1/2 and JNK but enhanced p38 activity ... Altered
CaMK activity
resulted in dysregulated
mitogen activated protein kinase signaling, demonstrated by reduced ERK 1/2 and JNK activity but enhanced p38 activity
Ahi et al., Behav Brain Res 2004
:
Inhibition of
CaMK II did not affect fear conditioning and
reduced the phosphorylation of
Erk-1/2 , Elk-1, CREB, and p90Rsk-1 only transiently, whereas Mek-1/2 inhibition was ineffective in all experiments