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APP — LRP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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MIPS CORUM APP-FE65-LRP complex:
APP-FE65-LRP complex complex (APBB1-APP-LRP1)
Pietrzik et al., J Neurosci 2004*
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IRef Corum Interaction:
Complex of APP-APP-APBB1-APBB1-LRP1-LRP1
(association, coimmunoprecipitation)
Pietrzik et al., J Neurosci 2004*
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Gene Ontology Complexes receptor complex:
receptor complex complex (PTH1R-TAOK2-VLDLR-TGFBR2-GABRG1-KCTD8-EGFR-RET-NTRK1-RIPK1-INSR-TRPC1-INSRR-GABRA5-FLT4-ADCYAP1R1-GPR37-P2RX2-LOXL4-IMPG2-PKD1L3-NOTCH1-ADRA2A-TRADD-LRP2-MTTP-GPR101-ITLN1-VIPR1-CD200R1-GRM7-GPR84-FCRL5-RNMT-ITGB1-NPR1-SLITRK5-IL4R-KCTD12-PLA2R1-RAMP1-RXRA-RAMP2-PIGR-GPR62-GPR63-GPR61-ITPR3-GPR20-MTNR1A-ROR1-ABCG5-CR2-GPR37L1-LRP1-LRP6-KCTD16-LRP5-CR1L-NTRK2-APP-GABRQ-CSF1-ABCG8-ADRB2-ADRB3-TLR7-GPR119-TAS1R2)
Roka et al., Mol Pharmacol 1999, Small et al., J Biol Chem 2000, Graf et al., J Biol Chem 2003, Breit et al., J Biol Chem 2004, Bomberger et al., J Biol Chem 2005, Turunen et al., Nucleic Acids Res 2007, Ding et al., J Cell Biol 2008, Ghai et al., Proc Natl Acad Sci U S A 2013, Lin et al., J Biol Chem 1995, Hsu et al., Immunity 1996, Zhang et al., Nature 1996
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IRef Hprd Interaction:
APP
—
LRP1
(in vivo)
Goto et al., J Mol Neurosci 2002*, Kounnas et al., Cell 1995*
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IRef Intact Interaction:
Complex of APBB1-LRP1-APP
(physical association, pull down)
Klug et al., FEBS Lett 2011*
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IRef Ophid Interaction:
APP
—
LRP1
(aggregation, confirmational text mining)
Kounnas et al., Cell 1995*
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IRef Ophid Interaction:
APP
—
LRP1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Hyman et al., Arch Neurol 2000
(Alzheimer Disease) :
In this review, we highlight data that support a role for LRP in A beta metabolism and hypothesize that
LRP therefore
plays a critical role in
Alzheimer disease
Pietrzik et al., J Neurosci 2004
:
We have shown previously that
LRP mediates beta-amyloid precursor protein (APP) processing and
affects amyloid beta-protein and APP secretion and
APP-c-terminal fragment generation ... Indeed, FE65 was only able to increase
APP secretion in the
presence of
LRP
Postuma et al., FEBS Lett 1998
(Alzheimer Disease) :
As LRP may regulate neurite outgrowth, we examined whether the effects of
APP are
mediated by
LRP ... Thus the effect of substrate bound
APP on neurite outgrowth is not
mediated by
LRP