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IL6 — RNF19A

Text-mined interactions from Literome

Zauberman et al., Oncogene 1999 (Carcinoma, Hepatocellular...) : Using a reporter gene construct containing a 190 bp promoter fragment of the acute phase protein haptoglobin we found that p38 is involved in transcriptional activation of the haptoglobin promoter by STAT3 but not by NF-IL6
Suzuki et al., FEBS Lett 2000 (Arthritis, Rheumatoid) : We examined the role of p38 mitogen activated protein ( MAP ) kinase in the tumor necrosis factor alpha (TNF-alpha)- or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity
Nakamura et al., Microbiol Immunol 2002 : The p38 inhibitor SB 203580 also suppressed their IL-6 production inducing activities, whereas the ERK1/2 activating MAPK kinase ( MEK1 ) inhibitor PD 98059 did not suppress their activities
Parker et al., Br J Pharmacol 2002 (MAP Kinase Signaling System) : 4. In wildtype mice, inhibition of p38 or ERK1/2 MAPKs significantly reduced IL-1beta induced IL-6 release, whilst the NFkappaB inhibitor caffeic acid phenethyl ester ( CAPE ) modulated IL-1 induced IL-6 release by action on NFkappaB and MAPKs pathways
Riedemann et al., FASEB J 2004 (MAP Kinase Signaling System...) : Production of IL-6 in neutrophils by LPS was NF-kappaB dependent ( but not on the presence of p50 ) and dependent on phosphorylation of p38-mitogen activated protein kinase ( MAPK ) as well as p44/p42 MAPK ( ERK1/2 ) but not on phosphorylation of c-Jun N-terminal kinases ( JNK1/2 )
Orabona et al., Nat Immunol 2004 (Candidiasis...) : Production of interleukin 6 required B7-1 ( CD80 ), B7-2 ( CD86 ) and p38 mitogen activated protein kinase and prevented interferon-gamma-driven expression of immunosuppressive tryptophan catabolism
Jeong et al., Hear Res 2005 (MAP Kinase Signaling System) : Increased IL-6 by DFX was significantly inhibited by p38 inhibitor, SB203580 ( about 72 % inhibition, P=0.027 ) but not ERK inhibitor, PD98059 or JNK inhibitor, SP600125
Colombara et al., J Immunol 2005 (MAP Kinase Signaling System...) : Constitutive activation of p38 and ERK1/2 MAPKs in epithelial cells of myasthenic thymus leads to IL-6 and RANTES overexpression : effects on survival and migration of peripheral T and B cells
Dai et al., Bone 2006 : In contrast, p38alpha/beta activation is not required for increased IL-6 mRNA or IL-6 protein secretion in either the early or late phases of stimulation by TNFalpha
Kandere-Grzybowska et al., Br J Pharmacol 2006 : The p38 inhibitor SB203580 and the PKC inhibitors Calphostin C and Gö6976 completely inhibited IL-1 induced IL-6 production
Lewthwaite et al., Int Immunopharmacol 2007 (Inflammation) : Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of MEK1/2, the direct upstream activator of ERK1/2 ( PD98059 ), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS
Shida et al., Biochem Biophys Res Commun 2007 (Prostatic Neoplasms) : p38MAPK activation is involved in androgen independent proliferation of human prostate cancer cells by regulating IL-6 secretion
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38 , and IKK inhibitors block TNF-alpha induced IL-8, IL-6 , and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Netea et al., Proc Natl Acad Sci U S A 2008 : Whereas the induction of TNFalpha, IL-1beta, and IL-6 by IL-32 is mediated by p38-MAPK , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3 dependent mechanisms
Roach et al., Neuroimmunomodulation 2008 (Astrocytoma...) : Although p38 and nuclear factor (NF)-kappaB are essential for the synergistic release of IL-6 , GABA did not affect either p38 phosphorylation or I kappaB-alpha degradation
Li et al., Exp Dermatol 2009 (Candidiasis, Cutaneous) : Anti-TLR2 neutralizing antibody, NFkappaB and p38MAPK inhibitors blocked the PLM induced secretion of IL-6 , IL-8 in keratinocytes, but no such effect was observed in pretreatment with anti-TLR4 neutralizing antibody and lipopolysaccharide inhibitor ( polymyxin B )
Shiba et al., J Endod 2009 (MAP Kinase Signaling System) : A p38 mitogen activated protein kinase inhibitor, SB203580, also inhibited the increase in IL-6 messenger RNA levels
Filer et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : The MAPKs p38 , JNK, and ERK were necessary for IL-6 production, but phosphatidylinositol 3-kinase ( PI 3-kinase ) was required for selective CCL5 induction
Feng et al., Br J Pharmacol 2010 : Inhibition of p38 by SB203580, and adenoviral transfer of dominant negative p38 inhibited NECA induced IL-6 production
Lee et al., J Biol Chem 2010 : At the intracellular level, both Smad and p38 signaling pathways are required for the induction of IL-6
Fan et al., J Cell Physiol 2011 : Inhibitors of AMPK ( araA ), p38MAPK ( SB202190 ), and ERK1/2 ( PD98059 and U0126 ) but not JNK ( SP600125 ) suppressed gAd induced IL-6 production
Kloesch et al., Rheumatol Int 2012 : Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1ß induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
Kurihara et al., Cell Metab 2011 (Osteitis Deformans) : Similarly, mice expressing only p62 ( P394L ) formed normal OCL, while mice expressing MVNP in OCL, with or without p62 ( P394L ), developed pagetic OCL and expressed high IL-6 levels dependent on p38MAPK activation
Jin et al., Mol Immunol 2011 (MAP Kinase Signaling System) : To explore the signaling mechanisms involved in the augmentation, we found that p38MAPK and NF?B pathways, but not ERK and JNK pathways, were required for the augmentation of IL-6 expression by coactivation of TLR4 and TLR2/6
Zhu et al., Acta Pharmacol Sin 2012 (MAP Kinase Signaling System) : Aldosterone treatment significantly increased the expression of Cox-2 and IL-6 and activation of p38MAPK and NF-?B
Kim et al., Parasite Immunol 2013 : N. fowleri mediated IL-1ß and IL-6 expression requires ERK, JNK and p38 mitogen activated protein kinases ( MAPKs ) activation in astrocytes
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : Both LIF and IL-6 [ in the absence of soluble IL-6 receptor ( sIL-6Ra ) ] activated Erk1/2, JNK1/2, p38-MAPK and PI3K signalling peaking at 20min and induced cytoprotection against simulated ischemia-reperfusion injury which was blocked by the MEK1/2 inhibitor PD98059 but not the p38-MAPK inhibitor SB203580
Hochdörfer et al., Cell Signal 2013 : LPS induced production of TNF-a and IL-6 in mast cells is dependent on p38 but independent of TTP
Choi et al., PloS one 2013 : In addition, phosphorylation of p38 , but not JNK, was responsible for the effects of glucose deprivation on IL-6 gene expression