Gene interactions and pathways from curated databases and text-mining

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IL1RN — MMP13

Text-mined interactions from Literome

Forsyth et al., Arthritis Rheum 2002 : However, the IL-1Ra partially inhibited FN-f induced activation of MMP-13
Xiang et al., Biomaterials 2012 (Arthritis) : The expression of IL-1Ra in synoviocytes then suppresses the expression of metalloproteases 13 ( MMP13 ) gene, which is responsible for cartilage destruction regulated by IL-1ß in arthritis