◀ Back to PTPN11
JAK2 — PTPN11
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
JAK2
→
PTPN11
(directlyDecreases, PTPN11 Activity, JAK2 Activity)
Evidence: SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus.
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KEGG Jak-STAT signaling pathway:
JAK1/JAK2/JAK3/TYK2
→
PTPN11
(protein-protein, phosphorylation)
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KEGG Adipocytokine signaling pathway:
JAK2
→
PTPN11
(protein-protein, activation)
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NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
GRB2/GAB2 complex (GRB2-GAB2)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database SHP2 signaling:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2)
→
SHP2 (PTPN11)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL5-mediated signaling events:
GRB2 (GRB2)
→
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11)
(modification, collaborate)
Pazdrak et al., J Exp Med 1997
Evidence: physical interaction
-
NCI Pathway Database IL5-mediated signaling events:
GRB2 (GRB2)
→
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2/GRB2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11-GRB2)
(modification, collaborate)
Pazdrak et al., J Exp Med 1997
Evidence: physical interaction
-
NCI Pathway Database IL5-mediated signaling events:
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11)
→
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2/GRB2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11-GRB2)
(modification, collaborate)
Pazdrak et al., J Exp Med 1997
Evidence: physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
SHP2 (PTPN11)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
SHP2 (PTPN11)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
SHP2 (PTPN11)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
Evidence: physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
SHP2 (PTPN11)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
Evidence: physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
Evidence: physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IL5-mediated signaling events:
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2)
→
SHP2 (PTPN11)
(modification, collaborate)
Pazdrak et al., J Exp Med 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL5-mediated signaling events:
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2)
→
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11)
(modification, collaborate)
Pazdrak et al., J Exp Med 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL5-mediated signaling events:
SHP2 (PTPN11)
→
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11)
(modification, collaborate)
Pazdrak et al., J Exp Med 1997
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
JAK2
→
PTPN11
(reaction)
Stahl et al., Science 1995*, Bone et al., J Biol Chem 1997, Symes et al., Curr Biol 1997*, Carpenter et al., Proc Natl Acad Sci U S A 1998*, Schaper et al., Biochem J 1998
-
Reactome Reaction:
JAK2
→
PTPN11
(indirect_complex)
Stahl et al., Science 1995*, Bone et al., J Biol Chem 1997, Symes et al., Curr Biol 1997*, Carpenter et al., Proc Natl Acad Sci U S A 1998*, Schaper et al., Biochem J 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PTPN11
—
JAK2
(direct interaction, enzymatic study)
Yin et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
PTPN11
—
JAK2
(direct interaction, pull down)
Yin et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
PTPN11
—
JAK2
(direct interaction, enzymatic study)
Tauchi et al., Blood 1996*
-
IRef Biogrid Interaction:
PTPN11
—
JAK2
(physical association, affinity chromatography technology)
Maegawa et al., Biochem Biophys Res Commun 1996*
-
IRef Hprd Interaction:
PTPN11
—
JAK2
(in vivo)
Fuhrer et al., J Biol Chem 1995*, Maegawa et al., Biochem Biophys Res Commun 1996*, Yin et al., J Biol Chem 1997*
-
IRef Ophid Interaction:
PTPN11
—
JAK2
(aggregation, confirmational text mining)
Yin et al., J Biol Chem 1997*
-
IRef Ophid Interaction:
PTPN11
—
JAK2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Li et al., Proc Natl Acad Sci U S A 1999
(Obesity) :
These data suggest that activation of
SHP-2 by the leptin receptor
results in a decreased phosphorylation of
JAK2 and may act to attenuate leptin signal transduction
Stofega et al., Mol Endocrinol 2000
:
These data suggest that tyrosine 595 is a major site of interaction of GHR with SHP-2, and that GHR bound
SHP-2 negatively
regulates GHR/JAK2 and STAT5B signaling
Kim et al., J Biol Chem 2006
:
Based on our previous finding that in cultured rat brain microglia, gangliosides induce rapid and transient activation of the JAK-STAT pathway, we hypothesized that raft mediated
SHP-2 activation is
involved in transient activation of
JAK-STAT signaling by gangliosides
Jia et al., PloS one 2010
:
In addition,
NS1 expression
induces up-regulation of the
JAK/STAT inhibitors, SOCS1 and SOCS3
Watanabe et al., J Biol Chem 1996
:
Further analyses of the role of JAK2 in c-fos gene activation in BA/F3 cells expressing hGMR revealed that delta
JAK2 inhibited hGM-CSF induced phosphorylation of Shc and
protein tyrosine phosphatase 1D
Mohi et al., Mol Biol Cell 1998
:
Conversely, activation of the chimeric
Jak2 induced neither phosphorylation of Shc or
SHP-2 nor activation of the c-fos promoter