Gene interactions and pathways from curated databases and text-mining

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CDKN1A — TNP1

Text-mined interactions from Literome

Yeh et al., Proc Natl Acad Sci U S A 2000 (Corneal Neovascularization) : The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest
Dabrowska-Iwanicka et al., J Cancer Res Clin Oncol 2002 (Colonic Neoplasms...) : The experiments revealed that TNP-470 together with IFN-gamma leads to the increased expression of p21 protein in cancer cells, which in turn may contribute to their cytostatic/cytotoxic action in vitro
Lien et al., Biochem Pharmacol 2004 : We have found that TNP-470 did not only induce p53 and p21 ( Cip1 ) but also cyclin D1 in the basic fibroblast growth factors (bFGF) treated endothelial cells