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CDKN1A — HRG
Text-mined interactions from Literome
Menendez et al., Int J Oncol 2005
(Breast Neoplasms) :
Pharmacological inactivation of the PI-3'K/AKT and MAPK completely prevented
HRG induced accumulation of
p21WAF1/CIP1 ... A structural deletion mutant of HRG ( HRG-M4 ) lacking the N-terminus sequence and the cytoplasmic-transmembrane region of HRG was generated to investigate whether secretion of
HRG and transactivation of Her-2/neu actively
contributed to HRG regulated
p21WAF1/CIP1 expression and cellular localization
Bacus et al., Oncogene 1996
(Breast Neoplasms...) :
The
NDF/HRG mediated
induction of
p21 is dependent on wildtype p53, as it fails to occur in cells expressing dominant negative p53 ( MDD2 )
Fiddes et al., Oncogene 1998
(Breast Neoplasms) :
p21 ( WAF1/CIP1/SDI1 ) gene expression was rapidly
induced by
HRG , but significant changes in p27 ( KIP1 ) protein levels were not detected ... Preincubation with PD98059 blocked the
HRG dependent induction of cyclin D1 mRNA,
p21 and c-Myc protein and pRB phosphorylation