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MCL1 — MYLIP
Text-mined interactions from Literome
Mott et al., Oncogene 2007
:
mir-29 regulates
Mcl-1 protein expression and apoptosis ... Enforced
mir-29b expression
reduced Mcl-1 protein expression in KMCH cells ... Enforced
mir-29b expression
reduced Mcl-1 cellular protein levels and sensitized the cancer cells to tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) cytotoxicity
Chen et al., J Hepatol 2009
(Bile Duct Neoplasms...) :
Moreover, the exogenous expression of
mir-320 or mir-204 could negatively
regulate Mcl-1 or Bcl-2 expression and facilitate chemotherapeutic drug triggered apoptosis
Su et al., Cancer Res 2009
(Carcinoma, Hepatocellular...) :
Further investigation revealed that
miR-101 significantly repressed the expression of luciferase carrying the 3'-untranslated region of Mcl-1 and
reduced the endogenous protein level of
Mcl-1 , whereas the miR-101 inhibitor obviously up-regulated Mcl-1 expression and inhibited cell apoptosis
Saito et al., Oncogene 2009
(Stomach Neoplasms) :
In addition, activation of
miR-512-5p by epigenetic treatment
induces suppression of
Mcl-1 , resulting in apoptosis of gastric cancer cells
Xu et al., Int J Cancer 2010
(Glioblastoma...) :
By luciferase reporter assays, we further showed that
miR-153 inhibited Bcl-2 and
Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs
Desjobert et al., Blood 2011
(Lymphoma, Large-Cell, Anaplastic) :
In addition, we showed that low expression of
miR-29a , probably through methylation repression,
plays an important regulatory role in
MCL-1 overexpression that could promote tumor cell survival by inhibiting apoptosis
Luo et al., Med Oncol 2012
(Carcinoma, Non-Small-Cell Lung...) :
Our results suggest that down-regulation of
miR-101 may
result in enhanced expression of
Mcl-1 in NSCLC, which consequently favored tumor progression
Kim et al., Leukemia & lymphoma 2012
(Lymphoma, B-Cell) :
Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab induced apoptosis through
miR-155 mediated Akt activation and up-regulation of
Mcl-1
Chen et al., Oncogene 2013
(Melanoma) :
In previous studies, we demonstrated that miR-193b expression is reduced in melanoma relative to benign nevi, and also that
miR-193b represses cyclin D1 and
Mcl-1 expression
Saito et al., Int J Cancer 2013
(Disease Progression...) :
Activation of
miR-29c by celecoxib induced suppression of
Mcl-1 and apoptosis in gastric cancer cells
Chen et al., Cancer Invest 2013
(Colonic Neoplasms) :
In this study, we investigated ALDH1A3, Mcl1, and
miR-125a/b expression in HT29 cells and the
effect of miR-125a/b on ALDH1A3 and
Mcl1 expression ... Overexpression of
miR-125a/b significantly
inhibited ALDH1A3 and
Mcl1 expression, reduced cell survival, and increased cell apoptosis in HT29-taxol cells
Li et al., CNS Neurosci Ther 2013
(Brain Neoplasms...) :
Overexpression of
miR-139 led to a clear decrease in
Mcl-1 expression in gliomas ... Our results suggested that
miR-139 negatively
regulated Mcl-1 and induced apoptosis in cooperation with an anticancer drug TMZ in glioma